Effect of a neuropsychological rehabilitation program focused on executive functions in a case of multiple sclerosis
DOI:
https://doi.org/10.21615/cesp.6104Keywords:
executive functions, multiple sclerosis, neurology, neuropsychology, neuropsychological rehabilitationAbstract
Multiple sclerosis is a demyelinating, inflammatory, neurodegenerative and autoimmune disease and as a consequence it can have neuropsychological alterations. The aim of this study was to establish the effect of a neuropsychological rehabilitation program, focused on executive functions, in a case with this pathology. For this, an experimental, non-A-B reversal single case design was proposed in a 69-year-old woman with 23 years of relapsing-remitting multiple sclerosis, functional status EDSS of 1 and mild neurocognitive disorder of the dysexecutive type. The rehabilitation plan had 12 sessions with a weekly frequency, 3 baseline measurements, and 4 measurements during the intervention process with the dysexective questionnaire (DEX-Sp). The results of the baseline, showed that the patient had a significant and stable dysexective disorder. In the intervention process, a progressive improvement of dysexective symptoms was observed, that is, there was a pattern of temporal change that impacted both her cognitive functioning and her daily activities. In the last measurement, a score in the lower limit of the normality range was obtained, which shows a cognitive improvement related to the patient neuropsychological rehabilitation program conducted.
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Amato, M., Langdon, D., Montalban, X., Benedict, R., DeLuca, J., Krupp, L., … Comi, G. (2013). Treatment of cognitive impairment in multiple sclerosis: Position paper. Journal of Neurology, 260(6), 1452-68. https://doi.org/10.1007/s00415-012-6678-0
Birnboim, S., & Miller, A. (2004). Cognitive Rehabilitation for Multiple Sclerosis Patients with Executive Dysfunction. The Journal of Cognitive Rehabilitation, 11-18.
Bono, R., & Arnau, J. (2014). Diseños de caso único en ciencias sociales y de la salud. Madrid: Síntesis.
Chaytor, N., Schmitter-Edgecombe, M., & Burr, R. (2006). Improving the ecological validity of executive functioning assessment. Archives of Clinical Neuropsychology, 21(3), 217-27. https://doi.org/10.1016/j.acn.2005.12.002
DeLuca, J., Chiaravalloti, N., & Sandroff, B. (2020). Treatment and management of cognitive dysfunction in patients with multiple sclerosis. Nature Reviews Neurology, 16, 319-332. https://doi.org/10.1038/s41582-020-0355-1
Domínguez, R., Morales, M., Rossiere, N., Olan, R., & Gutiérrez, J. (2012). Esclerosis múltiple: revisión de la literatura médica. Revista de la Facultad de Medicina de la UNAM, 5(55), 26-35.
Fernández, O., Aladro, Y., Arroyo, R., Brieva, Ll., Calles-Hernández, M., Carrascal, P., … Téllez, N. (2020a). XII Reunión Post-ECTRIMS: revisión de las novedades presentadas en el Congreso ECTRIMS 2019 (II). Revista de Neurología, 70(11), 417-429. https://doi.org/10.33588/rn.7010.2020121
Fernández, O., Aladro, Y., Arroyo, R., Brieva, Ll., Calles-Hernández, M., Carrascal, P.,… Rodríguez-Antiguedad, T. (2020b). XII Reunión Post-ECTRIMS: revisión de las novedades presentadas en el Congreso ECTRIMS 2019 (I). Revista de Neurología, 7(10), 379-390. https://doi.org/10.33588/rn.7010.2020121
Fink, F., Rischkau, E., Butt, M., Klein, J., Eling, P., & Hildebrandt, H. (2010). Efficacy of an executive function intervention programme in MS: a placebo-controlled and pseudo-randomized trial. Multiple Sclerosis, 16(9), 1148-51. https://doi.org/10.1177/1352458510375440
Fiorotto, S., & Martins, S. (2015). Relato de Experiência em Acompanhamento Cognitivo com um Paciente com Esclerose Múltipla. Psicologia: Ciência e Profissão, 35(3), 740-753. https://doi.org/10.1590/1982-3703001202014
García-Estévez, D., Fraga-González, C., Ramos-Pacho, M., López-Díaz, L., Pardo-Parrado, M., & Prieto, J. (2020). Prevalencia de la esclerosis múltiple en la ciudad de Ourense, Galicia, noroeste de la Península Ibérica. Revista de Neurología, 71(1), 19-25. https://doi.org/10.33588/rn.7101.2019432
García-Molina, A., & Enseñat, A. (2019). La rehabilitación neuropsicológica en el siglo xx. Revista de Neurología, 69(9), 383-391. https://doi.org/10.33588/rn.6909.2019247
Gich, J., Freixanet, J., García, R., Vilanova, J. Genís, D., & Silva, Y. (2015). A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: a cognitive rehabilitation programme for patients with multiple sclerosis. Multiple Sclerosis, 21(10), 1332-43. https://doi.org/10.1177/1352458515572405
Gil, M., Cerezo, M., Marasescu, R., Pinel, A., López, L., & Aladro, Y. (2013). Neuropsychological syndromes in multiple sclerosis. Psicothema, 25(4), 452-460. https://doi.org/10.7334/psicothema2012.308
Grosch, M., Gottlieb, M., & Cullum, M. (2011). Initial Practice Recommendations for Teleneuropsychology. The Clinical Neuropsychologist, 25(7), 1119-1133. https://doi.org/10.1080/13854046.2011.609840
Guarnizo, A., Bermúdez, S., Torres, Ó., Nassar, A., & Torres, C. (2016). Diagnóstico y evaluación de la esclerosis múltiple: lo que el radiólogo debe conocer e informar. Conceptos actuales. Revista Colombiana de Radiología, 27(4), 4543-55.
Hanssen, K., Beiske, A., Landrø, N., Hofoss, D., & Hessen, E. (2016). Cognitive rehabilitation in multiple sclerosis: a randomized controlled trial. Acta Neurologica Scandinavica, 133, 30–40. https://doi.org/10.1111/ane.12420
Hawker, K., & Frohman, E. (2004). Multiple Sclerosis. Primary Care: Clinics in Office Practice, 31, 201-26. https://doi.org/10.1016/S0095-4543(03)00123-4
Jiménez-Pérez, C., Zarco-Montero, L., Castañeda-Cardona, C., Otálora, M., Martínez, A., & Rosselli, D. (2015). Estado actual de la esclerosis múltiple en Colombia. Acta Neurológica Colombiana, 31(4), 385-390.
Juárez, G. (2010). Neurorrehabilitación del paciente con esclerosis múltiple. Revista Mexicana de Medicina Física y Rehabilitación, 22, 41-53.
Khan, F., & Amatya, B. (2017). Rehabilitation in multiple sclerosis: a systematic review of systematic reviews. Archives of Physical Medicine and Rehabilitation, 98(2), 353–367. https://doi.org/10.1016/j.apmr.2016.04.016
Lovera, J., & Kovner, B. (2012). Cognitive impairment in multiple sclerosis. Current Neurology and Neuroscience Reports, 12(5), 618–627. https://doi.org/10.1007/s11910-012-0294-3
Ma, H. (2006). An alternative method for quantitative synthesis of single-subjectresearches: percentage of data pointsexceeding the median. Behavior Modification, 30(5), 598-617. https://doi.org/10.1177/0145445504272974
Mattioli, F., Stampatori, C., Scarpazza, C., Parrinello, G., & Capra, R. (2012). Persistence of the effects of attention and executive functions intensive rehabilitation in relapsing remitting multiple sclerosis. Multiple Sclerosis and Related Disorders, 1(4), 168-173. https://doi.org/10.1016/j.msard.2012.06.004
Messinis, L., Papathanasopoulos, P., Kosmidis, M., Nasios, G., & Kambanaros, M. (2018). Neuropsychological Features of Multiple Sclerosis: Impact and Rehabilitation. Behavioural Neurology, 27, 1-4. https://doi.org/10.1155/2018/4831647
Ministerio de Salud, Colombia. Resolución No. 8430 de 1993. Normas Científicas, Técnicas y Administrativas para la Investigación en Salud.
Muñoz-Céspedes, J., & Tirapu-Ustárroz, J. (2004). Rehabilitación de las funciones ejecutivas. Revista de Neurología, 38(7), 656-663. https://doi.org/10.33588/rn.3807.2003411
Nilton, C., Montesinos, R., & López-Góngora, M. (2018). Deterioro cognitivo en pacientes con esclerosis múltiple. Anales de la Facultad de Medicina, 79(4), 338-45. https://doi.org/10.15381/anales.v79i4.15641
Pedrero-Pérez, E., Ruiz-Sánchez, J., Lozoya-Delgado, P., Llanero-Luque, M., Rojo-Mota, G., & Puerta-García, C. (2011). Evaluación de los síntomas prefrontales: propiedades psicométricas y datos normativos del cuestionario disejecutivo (DEX) en una muestra de población española. Revista de Neurología, 52(7), 394-404. https://doi.org/10.33588/rn.5207.2010731
Polman, C., Reingold, S., Banwell, B., Clanet, M., Cohen, J., Filippi, M., … Wolinsky, J. (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology, 69(2), 292-302. https://doi.org/10.1002/ana.22366
Povedano, B., Carvalho, G., Sánchez, I., Romero, F., & Yusta, A. (2019). Esclerosis múltiple. Medicine, 12(78), 4587-97. https://doi.org/10.1016/j.med.2019.05.010
Prosperini, l., Piattella, M., Giannì, C., & Pantano, P. (2015). Functional and Structural Brain Plasticity Enhanced by Motor and Cognitive Rehabilitation in Multiple Sclerosis. Neural Plasticity, 1-12. https://doi.org/10.1155/2015/481574
Rose, A. (2019). Esclerosis Múltiple. En Wilson, B., Winegardner, J., Van Heugten, C. & Ownsworth, T. (2019). Rehabilitación neuropsicológica: Manual Internacional. México: Manual Moderno.
Ruano, L., Portaccio, E., Goretti, B., Niccolai, C., Severo, M. Patti, F., … Amato, M. (2017). Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes. Multiple Sclerosis, 23(9), 1258–1267. https://doi.org/10.1177/1352458516674367
Scruggs, T., & Mastropieri, M. (1998). Summarizing single-subject research: issues and applications. Behavior Modification, 22(3), 221-242. https://doi.org/10.1177/01454455980223001
Shadish, W., & Sullivan, K. (2011). Characteristics of single-case designs used to assess intervention effects in 2008. Behavior Research Methods, 43(4), 971-980. https://doi.org/10.3758/s13428-011-0111-y
Shevil, E., & Finlayson, M. (2009). Pilot study of a cognitive intervention program for persons with multiple sclerosis. Health Education Research, 25(1), 41-53. https://doi.org/10.1093/her/cyp037
Sholberg, M., & Mateer, C. (1989). Introduction to cognitive rehabilitation. New York: The Guilford Press
Verdejo-García, A., & Bechara, A. (2010). Neuropsicología de las funciones ejecutivas. Psicothema, 22(2), 227-235.
Wilson, B., Alderman, N., Burgess, P., Emslie, H., & Evans, J. (1996). Behavioural assessment of the Dysexecutive Syndrome. Bury St. Edmunds, UK: Thames Valley Test Company.
Wilson, B., Winegardner, J., van Heugten, C., Ownsworth, T. (2017). Rehabilitación neuropsicológica, manual internacional. México: Manual moderno.
World Medical Association [WAM]. (2015). Declaración de Helsinki: Principios éticos para las investigaciones médicas en seres humanos. Declaración adaptada por el secretario de la WAM, tras emitirla en la 64a asamblea general (Octubre 2013). Fortaleza, Brasil.
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Copyright (c) 2022 Claudia Rocío López Gutiérrez, Margarita Castrillón Taba, Juan Pablo Lopera Vásquez
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