Comparación del rendimiento de pruebas cognitivas en pacientes con Enfermedad de Parkinson con y sin estimulación cerebral profunda

Autores/as

DOI:

https://doi.org/10.21615/cesp.5896

Palabras clave:

Enfermedad de Parkinson, estimulación cerebral profunda, evaluación neuropsicológica, funciones cognitivas, neurocirugía, Ganglios Basales

Resumen

Los pacientes diagnosticados con Enfermedad de Parkinson (EP) presentan alteraciones motoras concomitantes a otras alteraciones de tipo cognitivo, conductual o emocional. Una de las alternativas al tratamiento farmacológico es la estimulación cerebral profunda (ECP). Existen reportes de alteraciones en el rendimiento de tareas cognitivas tras procedimiento de ECP, lo que podría sugerir que el procedimiento es responsable de estos cambios cognitivos. El objetivo del estudio fue comparar los resultados del rendimiento en pruebas cognitivas de pacientes con EP de dos grupos (con ECP y sin ECP). Se recolectaron los resultados de 47 pacientes (n = 16 ECP; n = 31 sin ECP) durante los años de 2011 hasta 2015. Dentro de las funciones y variables evaluadas se encuentran: categorización visual, flexibilidad cognitiva, solución de problemas, atención selectiva, velocidad de procesamiento, inhibición conductual y calidad de vida. En general, no se encontraron diferencias significativas entre los grupos en las funciones evaluadas. En el grupo de participantes con ECP, se encontró mayor cantidad de correlaciones entre las pruebas de semejanzas y las de dígitos inversos, listas de palabras, búsqueda de símbolos y las subpruebas del Wisconsin Card Sorting Test. Así mismo, en los pacientes con ECP se presentó una percepción menor de calidad de vida asociada al tiempo de la enfermedad en comparación con el grupo sin ECP. En conclusión, estos resultados son congruentes con estudios similares de evaluación neuropsicológica y se discute el papel del tratamiento de estimulación en los pacientes, los cuales no siempre tienen un impacto positivo sobre la calidad de vida percibida.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Adriana Martínez-Martínez, Pontificia Universidad Javeriana

Facultad de Psicología. Pontificia Universidad Javeriana, Bogotá, Colombia. 

Wilson López-López, Pontificia Universidad Javeriana

Facultad de Psicología. Pontificia Universidad Javeriana, Bogotá, Colombia. 

Cesar Acevedo-Triana, Universidad Pedagógica y Tecnológica de Colombia

Escuela de Psicología. Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia.

Departamento de Neurobiología, Universidad de Alabama, Birmingham, Estados Unidos.

Referencias bibliográficas

Aguilar, O. M., Soto, C. A., & Esguerra, M. (2011). Cambios neuropsicológicos asociados a estimulación cerebral profunda en Enfermedad de Parkinson: Revisión Teórica. Suma Psicológica, 18(2), 89–98.

American Psychological Association. (2002). Ethical principles of psychologists and code of conduct. American Psychologist, 57, 1060-1073. http://dx.doi.org/10.1037/0003-066X.57.12.1060

Ardila, A., Goodkin, K., Concha, M., Lecusay, R., O’Mellan, S. … Al, E. (2003). HUMANS: una batería neuropsicológica para la evaluación de pacientes infectados con VIH-1. itle. Revista de Neurología, 36(8), 756–762.

Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and Treatment of Parkinson Disease: A Review. JAMA, 323(6), 548–560. https://doi.org/10.1001/jama.2019.22360

Barceló, E., Lewis, S., & Moreno, M. (2006). Funciones ejecutivas en estudiantes universitarios que presentan bajo y alto rendimiento académico. Psicología Desde El Caribe, 18, 109–138.

Bayram, E., Litvan, I., Wright, B. A., Grembowski, C., Shen, Q., & Harrington, D. L. (2021). Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson’s disease. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition, 28(6), 812–828. https://doi.org/10.1080/13825585.2020.1828804

Becerra, J. E., Zorro, O., Ruiz-Gaviria, R., Castañeda-Cardona, C., Otálora-Esteban, M. … Rosselli, D. (2016). Economic Analysis of Deep Brain Stimulation in Parkinson Disease: Systematic Review of the Literature. World Neurosurgery, 93, 44–49. https://doi.org/10.1016/j.wneu.2016.05.028

Bickel, S., Alvarez, L., Macias, R., Pavon, N., Leon, M., Fernandez, C. … Litvan, I. (2010). Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson’s disease. Parkinsonism & Related Disorders, 16(8), 535–539. https://doi.org/10.1016/j.parkreldis.2010.06.008

Biundo, R., Weis, L., Antonini, A., Berardelli, A., Olesen, J., Gustavsson, A. … Biundo, R. (2016). Cognitive decline in Parkinson’s disease: the complex picture. Npj Parkinson’s Disease, 2, 16018. https://doi.org/10.1038/npjparkd.2016.18

Biundo, R., Weis, L., Facchini, S., Formento-Dojot, P., Vallelunga, A., Pilleri, M., & Antonini, A. (2014). Cognitive profiling of Parkinson disease patients with mild cognitive impairment and dementia. Parkinsonism & Related Disorders, 20(4), 394–399. https://doi.org/10.1016/j.parkreldis.2014.01.009

Castelli, L., Rizzi, L., Zibetti, M., Angrisano, S., Lanotte, M., & Lopiano, L. (2010). Neuropsychological changes 1-year after subthalamic DBS in PD patients: A prospective controlled study. Parkinsonism & Related Disorders, 16(2), 115–118. https://doi.org/10.1016/j.parkreldis.2009.08.010

Combs, H. L., Folley, B. S., Berry, D. T. R., Segerstrom, S. C., Han, D. Y., Anderson-Mooney, A. J. … van Horne, C. (2015). Cognition and Depression Following Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus Pars Internus in Parkinson’s Disease: A Meta-Analysis. In Neuropsychology Review (Vol. 25, Issue 4, pp. 439–454). Springer New York LLC.

Ley 1090. Código Deontológico y Bioético del psicólogo, (2006). http://tribunales.colpsic.org.co/tribunales_archivos/LEY_1090_DE_2006_actualizada_mar%0Azo_2012.pdf%0AM

Costanza, A., Radomska, M., Bondolfi, G., Zenga, F., Amerio, A. … Nguyen, K. D. (2021). Suicidality Associated With Deep Brain Stimulation in Extrapyramidal Diseases: A Critical Review and Hypotheses on Neuroanatomical and Neuroimmune Mechanisms. Frontiers in Integrative Neuroscience, 15(April). https://doi.org/10.3389/fnint.2021.632249

Cyron, D., Funk, M., Deletter, M.-A., & Scheufler, K. (2010). Preserved cognition after deep brain stimulation (DBS) in the subthalamic area for Parkinson’s disease: a case report. Acta Neurochirurgica, 152(12), 2097–2100. https://doi.org/10.1007/s00701-010-0755-x

de la Peña, C., Fernández Medina, J. M., Parra Bolaños, N., & Martínez Restrepo, Ó. A. (2016). Estudio neuropsicológico en pacientes parkinsonianos: efectos de la estimulación cerebral profunda. Revista de Neurología, 62(04), 152. https://doi.org/10.33588/rn.6204.2015432

Demakis, G. J. (2007). The neuropsychology of Parkinson’s disease. Disease-a-Month: DM, 53(3), 152–155. https://doi.org/10.1016/j.disamonth.2007.04.005

Denheyer, M., Kiss, Z. H., & Haffenden, A. M. (2009). Behavioral effects of subthalamic deep brain stimulation in Parkinson’s disease. Neuropsychologia, 47(14), 3203–3209. https://doi.org/10.1016/j.neuropsychologia.2009.07.022

Deogaonkar, M., Monsalve, G. A., Scott, J., Ahmed, A., & Rezai, A. (2011). Bilateral subthalamic deep brain stimulation after bilateral pallidal deep brain stimulation for Parkinson’s disease. Stereotactic and Functional Neurosurgery, 89(2), 123–127. https://doi.org/10.1159/000323375

Dowsey-Limousin, P., & Pollak, P. (2001). Deep brain stimulation in the treatment of Parkinson’s disease: a review and update. Clinical Neuroscience Research, 1(6), 521–526. https://doi.org/10.1016/S1566-2772(01)00029-9

Duque, A. F., Lopez, J. C., Hernandez, H., Benitez, B., Yunis, J. J., Fernandez, W. … Arboleda, G. (2015). Analysis of the LRRK2 p.G2019S mutation in Colombian Parkinson’s Disease Patients. In Colombia Médica, 46 (3), 117–121. http://colombiamedica.univalle.edu.co/index.php/comedica/article/view/1553/2691

El-Nazer, R., Adler, C. H., Beach, T. G., Belden, C. M., Artz, J., Shill, H. A. … Benge, J. F. (2019). Regional neuropathology distribution and verbal fluency impairments in Parkinson’s disease. Parkinsonism & Related Disorders, 65, 73–78. https://doi.org/10.1016/j.parkreldis.2019.05.014

Elbaz, A., Carcaillon, L., Kab, S., & Moisan, F. (2016). Epidemiology of Parkinson’s disease. Revue Neurologique, 172(1), 14–26. https://doi.org/10.1016/j.neurol.2015.09.012

Elgebaly, A., Elfil, M., Attia, A., Magdy, M., & Negida, A. (2018). Neuropsychological performance changes following subthalamic versus pallidal deep brain stimulation in Parkinson’s disease: A systematic review and metaanalysis. CNS Spectrums, 23(1), 10–23. https://doi.org/10.1017/S1092852917000062

Evens, R., Stankevich, Y., Dshemuchadse, M., Storch, A., Wolz, M., Reichmann, H. … Lueken, U. (2015). The impact of Parkinson’s disease and subthalamic deep brain stimulation on reward processing. Neuropsychologia, 75, 11–19. https://doi.org/10.1016/j.neuropsychologia.2015.05.005

Fasano, A., Daniele, A., & Albanese, A. (2012). Treatment of motor and non-motor features of Parkinson’s disease with deep brain stimulation. The Lancet. Neurology, 11(5), 429–442. https://doi.org/10.1016/S1474-4422(12)70049-2

Foley, J. A., Niven, E. H., Abrahams, S., & Cipolotti, L. (2021). Phonemic fluency quantity and quality: Comparing patients with PSP, Parkinson’s disease and focal frontal and subcortical lesions. Neuropsychologia, 153, 107772. https://doi.org/10.1016/j.neuropsychologia.2021.107772

Galtier, I., Nieto, A., Barroso, J., & Lorenzo, N. (2009). Deterioro del aprendizaje visoespacial en la enfermedad de Parkinson. Psicothema, 21(1), 21–26.

Garzón-Giraldo, M. L. D., Montoya-Arenas, D. A., & Carvajal-Castrillón, J. (2015). Perfil clínico y neuropsicológico: enfermedad de Parkinson/enfermedad por cuerpos de Lewy. CES Medicina, 29(2), 255–270. https://doi.org/10.21615/cesmed.v29i2.3231

Glozman, J. (2013). Rehabilitation of superior psychological functions in patients with Parkinson syndrome. Neuropsicologia Latinoamericana, 5(spe), 58–65. https://doi.org/10.5579/rnl.2013.0119

Guerrero, S. (2004). Secuelas psiquiátricas y neuropsicológicas de la cirugía de epilepsia del Lóbulo temporal. Revista Colombiana de Psiquiatría, 33(4), 423–436.

Haelterman, N. A., Yoon, W. H., Sandoval, H., Jaiswal, M., Shulman, J. M., & Bellen, H. J. (2014). A mitocentric view of Parkinson’s disease. Annual Review of Neuroscience, 37, 137–159. https://doi.org/10.1146/annurev-neuro-071013-014317

Harrington, D. L., Shen, Q., Vincent Filoteo, J., Litvan, I., Huang, M., Castillo, G. … Bayram, E. (2020). Abnormal distraction and load-specific connectivity during working memory in cognitively normal Parkinson’s disease. Human Brain Mapping, 41(5), 1195–1211. https://doi.org/10.1002/hbm.24868

Heaton, R. (1981). A manual for the Wisconsin Card Sorting Test Manual. (Odessa: Ps).

Henao-Arboleda, E., Muñoz, C., Aguirre-Acevedo, D.C., Lara, E., Pineda, D. A., & Lopera, F. (2010). Datos normativos de pruebas neuropsicológicas en adultos mayores en una población Colombiana. Revista Chilena de Neuropsicologia, 213–225.

Hindle, J. V., Martyr, A., & Clare, L. (2014). Cognitive reserve in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism & Related Disorders, 20(1), 1–7. https://doi.org/10.1016/j.parkreldis.2013.08.010

Hobson, P., & Meara, J. (2015). Mild cognitive impairment in Parkinson’s disease and its progression onto dementia: a 16-year outcome evaluation of the Denbighshire cohort. International Journal of Geriatric Psychiatry, 30(10), 1048–1055. https://doi.org/10.1002/gps.4261

Huang, Y.-C., Wu, S.-T., Lin, J.-J., Lin, C.-C., & Kao, C.-H. (2015). Prevalence and risk factors of cognitive impairment in Parkinson disease: a population-based case-control study in Taiwan. Medicine, 94(17), e782. https://doi.org/10.1097/MD.0000000000000782

Hurtado, F., Cardenas, M. A., Cardenas, F. P., & León, L. A. (2016). La Enfermedad de Parkinson: etiología, tratamientos y factores preventivos. Universitas Psychologica1, 15(5), 1–26. https://doi.org/10.11144/Javeriana.upsy15-5.epet

John, K. D., Wylie, S. A., Dawant, B. M., Rodriguez, W. J., Phibbs, F. T., Bradley, E. B. … van Wouwe, N. C. (2021). Deep brain stimulation effects on verbal fluency dissociated by target and active contact location. Annals of Clinical and Translational Neurology, 8(3), 613–622. https://doi.org/10.1002/acn3.51304

Juri, C., Rodriguez-Oroz, M., & Obeso, J. a. (2010). The pathophysiological basis of sensory disturbances in Parkinson’s disease. Journal of the Neurological Sciences, 289(1–2), 60–65. https://doi.org/10.1016/j.jns.2009.08.018

Kurtis, M. M., Rajah, T., Delgado, L. F., & Dafsari, H. S. (2017). The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence. NPJ Parkinson’s Disease, 3, 16024. https://doi.org/10.1038/npjparkd.2016.24

Liu, Y., Li, W., Tan, C., Liu, X., Wang, X., Gui, Y. … Chen, L. (2014). Meta-analysis comparing deep brain stimulation of the globus pallidus and subthalamic nucleus to treat advanced Parkinson disease. Journal of Neurosurgery, 121(3), 709–718. https://doi.org/10.3171/2014.4.JNS131711

Lyons, M. K. (2011). Deep brain stimulation: current and future clinical applications. Mayo Clinic Proceedings, 86(7), 662–672. https://doi.org/10.4065/mcp.2011.0045

Martínez-Martín, P., & Frades Payo, B. (1998). Quality of life in Parkinson’s disease: validation study of the PDQ-39 Spanish version. The Grupo Centro for Study of Movement Disorders. Journal of Neurology, S34-8. http://www.ncbi.nlm.nih.gov/pubmed/9617722

Martínez-Martín, P., Serrano-Dueñas, M., & Vaca-Baquero, V. (2005). Psychometric characteristics of the Parkinson’s disease questionnaire (PDQ-39)--Ecuadorian version. Parkinsonism & Related Disorders, 11(5), 297–304. https://doi.org/10.1016/j.parkreldis.2005.02.003

Martinez-Martinez, A., Aguilar, O. M., & Acevedo-Triana, C. A. (2017). Meta-analysis of the relationship between deep brain stimulation (DBS) in patients with Parkinson’s disease and performance in evaluation tests for executive brain functions. Parkinson’s Disease, 2017(Article ID 9641392), 1–16. https://doi.org/10.1155/2017/9641392

McRae, C., Cherin, E., Yamazaki, T. G., Diem, G., Vo, A. H., Russell, D. … Freed, C. R. (2004). Effects of Perceived Treatment on Quality of Life and Medical Outcomesin a Double-blind Placebo Surgery Trial. Archives of General Psychiatry, 61(4), 412–420. https://doi.org/10.1001/archpsyc.61.4.412

Moreno, S., Buriticá, O., Franco, A., Pineda, N., Arias, W., Sepúlveda, D. … Lopera, F. (2010). Alteraciones cognitivas en Parkinson Juvenil causado por la mutación C212Y en el gen Parkin. International Journal of Psychological Research, 3(2), 55–62.

Negida, A., Elminawy, M., El Ashal, G., Essam, A., Eysa, A., & Abd Elalem Aziz, M. (2018). Subthalamic and Pallidal Deep Brain Stimulation for Parkinson’s Disease. Cureus, 10(2). https://doi.org/10.7759/cureus.2232

Oh, E. S., Lee, J. H., Seo, J. G., Sohn, E. H., & Lee, A. Y. (2011). Autonomic and cognitive functions in Parkinson’s disease (PD). Archives of Gerontology and Geriatrics, 52(1), 84–88. https://doi.org/10.1016/j.archger.2010.02.005

Orduz-Bastidas, L., Martínez-Martínez, A., Hurtado Parrado, C., López-López, W., & Acevedo-Triana, C. (2020). Parkinson disease patients’ performance in theory of mind (ToM) and decision-making tasks with and without deep brain stimulation (DBS). Terapia Psicologica, 38(2), 259–282. https://doi.org/10.4067/S0718-48082020000200259

Pagano, G., Ferrara, N., Brooks, D. J., & Pavese, N. (2016). Age at onset and Parkinson disease phenotype. Neurology, 86(15), 1400–1407. https://doi.org/10.1212/WNL.0000000000002461

Picillo, M., Vincos, G. B., Sammartino, F., Lozano, A. M., & Fasano, A. (2017). Exploring risk factors for stuttering development in Parkinson disease after deep brain stimulation. Parkinsonism & Related Disorders, 38, 85–89. https://doi.org/10.1016/j.parkreldis.2017.02.015

Ramos, A. A., & Machado, L. (2021). A Comprehensive Meta-analysis on Short-term and Working Memory Dysfunction in Parkinson’s Disease. Neuropsychology Review, 31(2), 288–311. https://doi.org/10.1007/s11065-021-09480-w

Rektorova, I. (2019). Current treatment of behavioral and cognitive symptoms of Parkinson’s disease. Parkinsonism & Related Disorders, 59, 65–73. https://doi.org/10.1016/j.parkreldis.2019.02.042

Rodríguez-Violante, M., Velázquez-Osuna, S., Cervantes-Arriaga, A., Corona-Vázquez, T., & de la Fuente-Sandoval, C. (2015). Prevalencia, factores asociados y fenomenología de la psicosis en pacientes con enfermedad de Parkinson. Gaceta Médica de México, 151, 169–175.

Sáez-Francàs, N., Martí Andrés, G., Ramírez, N., de Fàbregues, O., Álvarez-Sabín, J., Casas, M., & Hernández-Vara, J. (2016). Factores clínicos y psicopatológicos asociados a los trastornos del control de impulsos en la enfermedad de Parkinson. Neurología, 31(4), 231–238. https://doi.org/10.1016/j.nrl.2015.05.002

Schoenberg, M. R., Mash, K. M., Bharucha, K. J., Francel, P. C., & Scott, J. G. (2008). Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson’s disease. Stereotactic and Functional Neurosurgery, 86(6), 337–344. https://doi.org/10.1159/000163554

Siegert, R. J., Weatherall, M., Taylor, K. D., & Abernethy, D. A. (2008). A Meta-Analysis of Performance on Simple Span and More Complex Working Memory Tasks in Parkinson’s Disease. Neuropsychology Review, 22 (4)(4), 450–461.

Stoessl, A. J. (2011). Neuroimaging in Parkinson’s Disease. Neurotherapeutics, 8(1), 72–81. https://doi.org/10.1007/s13311-010-0007-z

Tröster, A. I. (2017). Some Clinically Useful Information that Neuropsychology Provides Patients, Carepartners, Neurologists, and Neurosurgeons about Deep Brain Stimulation for Parkinson’s Disease. Archives of Clinical Neuropsychology, 32(7), 810–828. https://doi.org/10.1093/arclin/acx090

Walker, A., Batchelor, J., Shores, A., & Jones, M. (2009). Diagnostic efficiency of demographically corrected Wechsler Adult Intelligence Scale-III and Wechsler Memory Scale-III indices in moderate to severe traumatic brain injury and lower education levels. Journal of the International Neuropsychological Society, 15, 938–950.

Wu, B., Han, L., Sun, B.-M., Hu, X.-W., & Wang, X.-P. (2014). Influence of deep brain stimulation of the subthalamic nucleus on cognitive function in patients with Parkinson’s disease. Neuroscience Bulletin, 30(1), 153–161. https://doi.org/10.1007/s12264-013-1389-9

Xie, C. L., Shao, B., Chen, J., Zhou, Y., Lin, S. Y., & Wang, W. W. (2016). Effects of neurostimulation for advanced Parkinson’s disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials. Scientific Reports, 6(May), 1–11. https://doi.org/10.1038/srep25285

Xu, H., Zheng, F., Krischek, B., Ding, W., Xiong, C., Wang, X., & Niu, C. (2017). Subthalamic nucleus and globus pallidus internus stimulation for the treatment of Parkinson’s disease: A systematic review. Journal of International Medical Research, 45(5), 1602–1612. https://doi.org/10.1177/0300060517708102

Zangaglia, R., Pacchetti, C., Pasotti, C., Mancini, F., Servello, D., Sinforiani … Nappi, G. (2009). Deep brain stimulation and cognitive functions in Parkinson’s disease: A three-year controlled study. Movement Disorders, 24(11), 1621–1628. https://doi.org/10.1002/mds.22603

Zhang, J., Li, J., Chen, F., Liu, X., Jiang, C., Hu, X. … Xu, Z. (2021). STN versus GPi deep brain stimulation for dyskinesia improvement in advanced Parkinson’s disease: A meta-analysis of randomized controlled trials. Clinical Neurology and Neurosurgery, 201(December 2020), 106450. https://doi.org/10.1016/j.clineuro.2020.106450

Descargas

Publicado

2022-05-20

Cómo citar

Martínez-Martínez, A., López-López, W., & Acevedo-Triana, C. (2022). Comparación del rendimiento de pruebas cognitivas en pacientes con Enfermedad de Parkinson con y sin estimulación cerebral profunda. CES Psicología, 15(2), 1–22. https://doi.org/10.21615/cesp.5896

Número

Sección

Artículos Originales