Dermatitis herpetiformis: specific manifestation of celiac disease
DOI:
https://doi.org/10.21615/cesmedicina.6352Keywords:
celiac disease, skin diseases, dermatitis herpetiformis, diet, gluten-freeAbstract
Celiac disease is a systemic disorder with an autoimmune basis, secondary to continuous exposure to gluten in people with genetic susceptibility, which leads to the development of specific antibodies mainly affecting the small intestine with subsequent enteropathy. The clinical manifestations include digestive symptoms and extra intestinal manifestations. In this last group, the dermatological manifestations stand out, specifically dermatitis herpetiformis, which is considered specific to Celiac disease. It presents clinically as a pruritic papulovesicular rash. The diagnosis is based on a skin biopsy with direct immunofluorescence and the presence of anti-tissue transglutaminase 2 antibodies, only in specific cases it should be complemented with other studies. Treatment is based on a gluten-free diet, which improves symptoms, controls and prevents complications of Celiac disease, such as digestive neoplasms and the development of other autoimmune diseases.
Downloads
References
Rubin JE, Crowe SE. Celiac Disease. Ann Intern Med. 2020;172(1): ITC1-16. DOI: 10.7326/AITC202001070
Bureš J. History of celiac disease. Vnitr Lek. 2018;64(6):600-1. URL: https://pubmed.ncbi.nlm.nih.gov/30223657/
Yu XB, Uhde M, Green PH, Alaedini A. Autoantibodies in the Extraintestinal Manifestations of Celiac Disease. Nutrients. 2018;10(8): E1123. DOI: 10.3390/nu10081123
Parra-Medina R, Molano-Gonzalez N, Rojas-Villarraga A, Agmon-Levin N, Arango M-T, Shoenfeld Y, et al. Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression. PLOS ONE. 2015;10(5): e0124040. DOI: 10.1371/journal.pone.0124040
Therrien A, Kelly CP, Silvester JA. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol. 2020;54(1): 8-21. DOI: 10.1097/MCG.0000000000001267
Abenavoli L, Dastoli S, Bennardo L, Boccuto L, Passante M, Silvestri M, et al. The Skin in Celiac Disease Patients: The Other Side of the Coin. Medicina (Mex). 2019;55(9): 578. DOI: 10.3390/medicina55090578
Leffler DA, Green PHR, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015;12(10): 561-71. DOI: 10.1038/nrgastro.2015.131
Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet Lond Engl. 2018;391(10115): 70-81.
Antiga E, Maglie R, Quintarelli L, Verdelli A, Bonciani D, Bonciolini V, et al. Dermatitis Herpetiformis: Novel Perspectives. Front Immunol. 2019;10: 1290. DOI: 10.3389/fimmu.2019.01290
Salmi TT. Dermatitis herpetiformis. Clin Exp Dermatol. 2019;44(7): 728-31. DOI: 10.1111/ced.13992
Sanjinés DL. Dermatitis herpetiforme como carta de presentación de la enfermedad celíaca. Rev Urug Med Interna. 2016;7. URL: http://www.scielo.edu.uy/pdf/rumi/v1n1/v1n1a03.pdf
J. FM, P. RQ. Enfermedad celiaca: Revisión. Rev Médica Clínica Las Condes. 2015;26(5): 613-27.
Rojas-Vargas C. Enfermedad celíaca: una enfermedad autoinmune. Rev Médica Sinerg. 2021;6: 11. DOI: 10.1016/j.rmclc.2015.09.007
Jericho H, Sansotta N, Guandalini S. Extraintestinal Manifestations of Celiac Disease: Effectiveness of the Gluten-Free Diet. J Pediatr Gastroenterol Nutr. 2017;65(1):75-9. DOI: 10.1097/MPG.0000000000001420
Muddasani S, Rusk AM, Baquerizo Nole KL. Gluten and skin disease beyond dermatitis herpetiformis: a review. Int J Dermatol. 2021;60(3):281-8. DOI: 10.1111/ijd.15098
Salmi TT, Hervonen K, Kautiainen H, Collin P, Reunala T. Prevalence and incidence of dermatitis herpetiformis: a 40-year prospective study from Finland. Br J Dermatol. 2011;165(2): 354-9. DOI: 10.1111/j.1365-2133.2011.10385.x
Mansikka E, Hervonen K, Kaukinen K, Collin P, Huhtala H, Reunala T, et al. Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis. Nutrients. 2018;10(5): E641. DOI: 10.3390/nu10050641
Lindfors K, Ciacci C, Kurppa K, Lundin KEA, Makharia GK, Mearin ML, et al. Coeliac disease. Nat Rev Dis Primer. 2019;5(1): 3.
Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010;105(12):2520-4.
Pallav K, Kabbani T, Tariq S, Vanga R, Kelly CP, Leffler DA. Clinical Utility of Celiac Disease-Associated HLA Testing. Dig Dis Sci. 2014;59(9): 2199-206. DOI: 10.1038/s41572-018-0054-z
Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, et al. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014;63(8): 1210-28. DOI: 10.1136/gutjnl-2013-306578
Downey L, Houten R, Murch S, Longson D, Guideline Development Group. Recognition, assessment, and management of coeliac disease: summary of updated NICE guidance. BMJ. 2015;351:h4513.
Antiga E, Caproni M. The diagnosis and treatment of dermatitis herpetiformis. Clin Cosmet Investig Dermatol. 2015;8:257-65. DOI: 10.2147/CCID.S69127
Rodrigo L, Beteta-Gorriti V, Alvarez N, Gómez de Castro C, de Dios A, Palacios L, et al. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. Nutrients. 2018;10(7):E800. DOI: 10.3390/nu10070800
Baptista A, Madanelo S, Morais P. A pruritic vesicular rash. Aust Fam Physician. 2017;46(1):45-7.
Syage JA, Green PHR, Khosla C, Adelman DC, Sealey-Voyksner JA, Murray JA. Latiglutenase Treatment for Celiac Disease: Symptom and Quality of Life Improvement for Seropositive Patients on a Gluten-Free Diet. GastroHep. 2019;1(6):293-301. DOI: 10.1002/ygh2.371
Ja M, Cp K, Phr G, A M, Tt W, M M, et al. No Difference Between Latiglutenase and Placebo in Reducing Villous Atrophy or Improving Symptoms in Patients With Symptomatic Celiac Disease. Gastroenterology. 2021];152(4). URL:https://pubmed.ncbi.nlm.nih.gov/27864127/
Zingone F, Abdul Sultan A, Crooks CJ, Tata LJ, Ciacci C, West J. The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study. Aliment Pharmacol Ther. 2016;44(1):57-67. DOI: 10.1111/apt.13652
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 CES Medicina
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Derechos de reproducción (copyright)
Cada manuscrito se acompañará de una declaración en la que se especifique que los materiales son inéditos, que no han sido publicados anteriormente en formato impreso o electrónico y que no se presentarán a ningún otro medio antes de conocer la decisión de la revista. En todo caso, cualquier publicación anterior, sea en forma impresa o electrónica, deberá darse a conocer a la redacción por escrito.
Plagios, duplicaciones totales o parciales, traduccones del original a otro idioma son de responsabilidad exclusiva de los autores el envío.
Los autores adjuntarán una declaración firmada indicando que, si el manuscrito se acepta para su publicación, los derechos de reproducción son propiedad exclusiva de la Revista CES Medicina.
Se solicita a los autores que proporcionen la información completa acerca de cualquier beca o subvención recibida de una entidad comercial u otro grupo con intereses privados, u otro organismo, para costear parcial o totalmente el trabajo en que se basa el artículo.
Los autores tienen la responsabilidad de obtener los permisos necesarios para reproducir cualquier material protegido por derechos de reproducción. El manuscrito se acompañará de la carta original que otorgue ese permiso y en ella debe especificarse con exactitud el número del cuadro o figura o el texto exacto que se citará y cómo se usará, así como la referencia bibliográfica completa.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
