Genomic and cytogenetic panorama of acute myeloid leukemias with recurrent genetic abnormalities
DOI:
https://doi.org/10.21615/cesmedicina.34.2.4Keywords:
Acute myeloid leukemia, Mutation, Genetics, Cytogenetic abnormalities, PrognosisAbstract
Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature cells. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses.
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