Cardiovascular compromise secondary to metastatic carcinoid tumor

Authors

DOI:

https://doi.org/10.21615/cesmedicina.34.3.7

Keywords:

Carcinoid heart disease, Carcinoid tumor, Malignant carcinoid syndrome

Abstract

Carcinoid tumors are neoplasms belonging to the neuroendocrine tumor family and have a low incidence in the general population; however, up to 50% may debut with cardiovascular involvement. We present the case of a patient, without a cardiovascular history, who presented signs and symptoms suggestive of right-sided heart failure. A transthoracic echocardiogra phy was performed, which evidenced the involvement of both right heart
valves by a metastatic neuroendocrine tumor, leading to the diagnosis of carcinoid syndrome. In order to take this entity into account in the daily practice of clinical cardiology, key data of diagnostic and therapeutic approach are reviewed.

Downloads

Download data is not yet available.

References

Bhattacharyya S, Davar J, Dreyfus G, Caplin ME. Carcinoid Heart Disease. Circulation. 2007;116(24):2860-5.

Paredes A, Valdebenito M, Neira V, Castro P, Zalaquett R. Síndrome carcinoide y compromiso valvular cardíaco. Rev Chil Cardiol. 2014;33(1):38-43.

Davar J, Connolly HM, Caplin ME, Pavel M, Zacks J, Bhattacharyya S, et al. Diagnosing and managing carcinoid heart disease in patients with neuroendocrine tumors. J Am Coll Cardiol. 2017;69(10):1288-304.

Shah PM. Valvulopatía tricuspídea y pulmonar: evaluación y tratamiento. Rev Esp Cardiol. 2010;63(11):1349-65.

Møller JE, Pellikka PA, Bernheim AM, Schaff HV, Rubin J, Connolly HM. Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation. 2005;112(21):3320-7.

Hassan SA, Banchs J, Iliescu C, Dasari A, Lopez-Mattei J, Yusuf SW. Carcinoid heart disease. Heart. 2017;103(19):1488-95.

Perry D, Hayek SS. Carcinoid Heart Disease. Cardiol Clin. 2019;37(4):497-503.

Møller JE, Connolly HM, Rubin J, Seward JB, Modesto K, Pellikka PA. Factors associated with progression of carcinoid Heart Disease. N Engl J Med. 2003;348(11):1005-15.

Simula DV, Edwards WD, Tazelaar HD, Connolly HM, Schaff HV. Surgical Pathology of Carcinoid Heart Disease: A Study of 139 Valves From 75 Patients Spanning 20 Years. Mayo Clin Proc. 2002;77(2):139-47.

Bhattacharyya S, Toumpanakis C, Burke M, Taylor AM, Caplin ME, Davar J. Features of carcinoid heart disease identified by 2- and 3-dimensional echocardiography and cardiac MRI. Circ Cardiovasc Imaging. 2010;3(1):103-11.

Maria Alegret J, Subirana MT, Marcuello E, Bayés-Genís A, Ferrés P, Torner M. Afectación valvular tricuspídea y pulmonar en un caso de síndrome carcinoide. Rev Esp Cardiol. 1997;50(7):532-4.

Connolly HM, Schaff HV, Mullany CJ, Rubin J, Abel MD, Pellikka PA. Surgical management of left-sided carcinoid heart disease. Circulation. 2001;104:I-36-I-40.

Fox DJ. Carcinoid heart disease: presentation, diagnosis, and management. Heart. 2004;90(10):1224-8.

Luis SA, Pellikka PA. Carcinoid heart disease: Diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2016;30(1):149-58.

Korse CM, Taal BG, de Groot CA, Bakker RH, Bonfrer JMG. Chromogranin-A and N-Terminal pro-brain natriuretic peptide: an excellent pair of biomarkers for diagnostics in patients with neuroendocrine tumor. J Clin Oncol. 2009;27(26):4293-9.

Bhattacharyya S, Toumpanakis C, Chilkunda D, Caplin ME, Davar J. Risk Factors for the Development and Progression of Carcinoid Heart Disease. Am J Cardiol. 2011;107(8):1221-6.

Zuetenhorst JM, Bonfrer JMGM, Korse CM, Bakker R, van Tinteren H, Taal BG. Carcinoid heart disease: The role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth factor-Beta and fibroblast growth factor. Cancer 2003;97(7):1609-15.

Pandya UH, Pellikka PA, Enriquez-Sarano M, Edwards WD, Schaff HV, Connolly HM. Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients. J Am Coll Cardiol. 2002;40(7):1328-32.

Matshela MR. Cases in a series of carcinoid syndrome and carcinoid heart disease. Cardiovasc J Afr. 13 de septiembre de 2018;29(4):e1-7.

Ferrari A, Glasberg J, Riechelmann R. Carcinoid syndrome: update on the pathophysiology and treatment. Clinics 2018;73.

Steeds RP, Sagar V, Shetty S, Oelofse T, Singh H, Ahmad R, et al. Multidisciplinary team management of carcinoid heart disease. Endocr Connect. 2019;8(12):R184-99.

Lillegard JB, Fisher JE, Mckenzie TJ, Que FG, Farnell MB, Kendrick ML, et al. Hepatic Resection for the carcinoid syndrome in patients with severe carcinoid heart disease: does valve replacement permit safe hepatic resection? J Am Coll Surg. 2011;213(1):130-6.

Mujtaba SS, Clark S. Carcinoid Heart Disease: Early outcomes after surgical valve replacement in nine patients. Heart Surg Forum. 16 de febrero de 2018;21(1):040.

Bonou M, Kapelios CJ, Kaltsas G, Perreas K, Toutouzas K, Barbetseas J. Cardiac Surgery for carcinoid heart disease: a weapon not to be misused. Cardiology. 2017;136(4):243-51.

Mujtaba SS, Clark S. Quadruple Valve replacement for carcinoid heart disease. Braz J Cardiovasc Surg. 2018;33(4).

Heidecker B, Moore P, Bergsland EK, Merrick SH, Rao RK. Transcatheter pulmonic valve replacement in carcinoid heart disease. Eur Heart J - Cardiovasc Imaging. 2015.

Published

2020-12-09

How to Cite

Mejía Zuluaga, M., Bedoya Jaramillo, T. M., Duarte Suárez, N. R., Naranjo Restrepo, S., & Duque Ramírez, M. (2020). Cardiovascular compromise secondary to metastatic carcinoid tumor. CES Medicina, 34(3), 228–235. https://doi.org/10.21615/cesmedicina.34.3.7

Issue

Section

Reporte de caso
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views