• Óscar Alejandro Bonilla-Sepulveda Professor PostGraduate Gynecology and Obstetrics UniRemington, Medellín, Colombia.
  • Diana Carolina Giraldo-Santa Universidad de Caldas



Introduction: Mastalgia is a frequent clinical symptom in general and gynecological medicine consultation. The objectives of this bibliographical review are: to define the diagnostic concept, classification and treatment of mastalgia.

Methods: literature search in Pubmed, Scielo, Cochrane and Google Scholar, using the MeSH terms: mastodynia, mastalgia, breast pain, chest pain. The search limits were: full texts in English and Spanish, in humans and published during the last 10 years.

Results: the physiopathology of the mastodynia is not caused by a single mechanism, but by different causes with independent pathways. The main mechanisms are hormonal, mammary density, neuropathic and extra-mammary.

Conclusion: It is important to know the pathophysiology and classification of mastodynia, due to its therapeutic implications and possible association with breast cancer.


Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Óscar Alejandro Bonilla-Sepulveda, Professor PostGraduate Gynecology and Obstetrics UniRemington, Medellín, Colombia.

fellow mastologia CES 2014

Referencias bibliográficas

1. Davies EL, Gateley CA, Miers M, Mansel RE. The long-term course of mastalgia. J R Soc Med 1998; 91:462–464.

2. Dixon JM. Managing breast pain. Practitioner 1999; 243:484–486; 488–489; 491.

3. Ader DN, South-Paul J, Adera, Deuster PA. Cyclycal mastalgia: Prevalence and associated health and behavioral factors. J Psychosom Obstet Gynecol 2001; 22:71–76.

4. Gateley CA, Maddox PR, Pritchard GA, Sheridan W, Harrison BJ, Pye JK, et al. Plasma fatty acid profiles in benign breast disorders. Br J Surg 1992; 79:407–409.

5. Hughes LE, Mansel RE, Webster DJ, eds. Breast pain and nodularity. In: Benign disorders and diseases of the breast: concepts and clinical management. Philadelphia: Bailliere Tindall, 1989, pp 75–92.

6. Parlati E Travaglini A, Liberale I, menini E, Dell’Ácqua Al. Hormonal profile in benign breast disease: Endocrine status of cyclical mastalgia patients. J Endocrinol Invest 1988; 11:679–683.

7. Horrobin DF, Manku MS. Premenstrual syndrome and premenopausal breast pain (cyclical mastalgia): disorders of essential fatty acid (EFA) metabolism. Prostaglandins Leukot Essent Fatty Acids 1989; 37:255–261.

8. Preece PE, Richards AR, Owen GM. Mastalgia and total body water. Br Med J 1975; 4:498–500

9. Kumar S, Rai R, Das V, Dwivedi V, Kumar S, GG A. Visual analogue scale for assessing breast nodularity in non discrete lumpy breasts: the Lucknow Cardiff breast nodularity scale. The Breast 2010; 19:238–242

10. Wisbey JR, Kumar S, Mansel RE, Preece PE, Pye JK, Hughes LE. Natural history of breast pain. Lancet 1983;ii:672–674

11. Ernster VL, Mason L, Goodson WH. Effects of caffeine free diet on benign breast disease: a randomized trial. Surgery 1982; 91:263– 267

12. Klimberg SV. Etiology and management of breast pain. In: Bland KI, Copeland EM, eds. The Breast: Comprehensive Management of Benign and Malignant Diseases, 2nd Ed. Philadelphia: WB Saunders Co; 1998, pp 247–260.

13. Hadi MS. Sports brassiere: is it a solution for mastalgia? Breast J 2000; 6:407–409

14. Fox H, Walker RG, Heys SD. Are patients with mastalgia anxious, and does relaxation therapy help? Breast 1997;6: 138–142.

15. Russell LC. Caffeine restriction as initial treatment of breast pain. Nurse Pract 1989; 14:36–37.

16. Ernster VL, Goodson WHD, Hunt TK, Petrakis NL, Sickles, Mike R. Vitamin E and benign breast disease: A double-blind, randomized clinical trial. Surgery 1985; 97:490–494.

17. Shurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomized controlled trials. BMJ 2010;341:c5702–1315. doi:10.1136/c5702

18. 84. Sharma AK, Mishra SK, Salila M et al. Cyclical mastalgia: Is it a manifestation of aberration in lipid metabolism? Indian J Physiol Pharm 1994; 38:267–271.

19. Goyal A, Mansel RE. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Breast J 2005; 11:41–47

20. Colak T, Ipek T, Kanik A Efficacy of topical nonsteroidal antiinflammatory drugs in mastalgia treatment. J Am Coll Surg 2003; 196:525–530

21. Sutton GLC, O’Malley UP. Treatment of cyclical mastalgia with low-dose short-term danazol. Br J Clin Pract 1986; 40:68.

22. Fentiman IS, Powles TJ. Tamoxifen and benign breast problems. Lancet 1987; 26(8567):1070–1072.

23. Mansel RE, Dogliotti L. European Multicenter Trial of bromocriptine in cyclical mastalgia. Lancet 1990; 335:190–193.

24. Mansel RE, Goyal A, Preece P, Leinster S, Maddox PR (2004) European randomized multicenter study of goserelin (Zoladex) in the management of mastalgia. Am J Obstet Gynecol 2004; 191(6):1942–1949

25. Peters F. Multicenter study of gestrinone in cyclical breast pain. Lancet 1991; 339:205.

26. Uzan S, Denis C, Pomi V, Varin C. Double-blind trial of promegestone (R 5020) and lynestrenol in the treatment of benign breast disease. Eur J Obstet Gynecol Reprod Biol 1992; 43:219–227

27. Coney P, Washenik K, Langley RG, Harrison DD. Weight change and adverse event incidence with a low-dose oral contraceptive: two randomized, placebo-controlled trials. Contraception 2001; 63:297–302

28. Steinbrunn BS, Zera RT, Rodriguez JL Mastalgia: tailoring treatment to type of breast pain. Postgrad Med 1997;102(5):183–184,187-9,193-4

29. Maddox PR, Harrison BJ, Mansel RE et al. Non-cyclical mastalgia:An improved classification and treatment. Br J Surg 1989; 76:901–904.




Cómo citar

Bonilla-Sepulveda, Óscar A., & Giraldo-Santa, D. C. (2019). Mastodynia. CES Medicina, 33(2), 111–118.



Revisión de tema
Estadísticas de artículo
Vistas de resúmenes
Vistas de PDF
Descargas de PDF
Vistas de HTML
Otras vistas