Clasificación de heridas cutáneas y técnicas terapéuticas para la reparación de la piel

Autores/as

DOI:

https://doi.org/10.21615/cesenferm.7262

Palabras clave:

piel, heridas, biomaterial, técnicas terapéuticas, reparación de tejidos

Resumen

Las heridas de piel son un problema de salud pública mundial, las cuales cobran alrededor de trescientas mil vidas cada año y generan discapacidades a millones más. Más del 95% de estas lesiones ocurren en países en desarrollo, donde el acceso a los servicios de salud es complicado y los recursos son escasos. Variables como la profundidad, la causa, el nivel de infección y/o la cronicidad determinan el resultado de las heridas en la piel y si estas impedirán el proceso de curación natural del cuerpo. Para el tratamiento de heridas cutáneas profundas, crónicas y/o complicadas se han desarrollado diferentes tratamientos. Las técnicas tradicionales ampliamente utilizadas como la asepsia, el desbridamiento y la cirugía, tienen como objetivo prevenir daños mayores y ayudar a la cicatrización, pero tienen muchas desventajas, entre las que se encuentran resultados de baja eficiencia, altas tasas de tiempo de curación y costos elevados. Estrategias alternativas y novedosas como los apósitos bioactivos y la medicina regenerativa pretenden alcanzar una recuperación funcional y estética del tejido, minimizando el riesgo de rechazo presente en otras técnicas como colgajos e injertos de piel. La presente revisión muestra las principales características de la piel, una descripción general de los tipos de heridas más comunes y su incidencia, así como las estrategias de ingeniería tisular que se utilizan para la regeneración del tejido cutáneo.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Sara María Galvis Escobar, Universidad CES

Researcher Biomedical Engineering Program, Engineering Faculty, Universidad CES.

Juan David Molina Sierra, Universidad CES

Researcher Veterinary Medicine and Zootechnics, Veterinary Medicine and Zootechnics Faculty, Universidad CES.

Juan Pablo Ruíz Soto, Universidad CES

Biomedical Engineering Student, Engineering Faculty, Universidad CES.

Maria Antonia Rego Londoño, Universidad CES

Biomedical Engineering Student, Engineering Faculty, Universidad CES.

Catalina Pineda Molina, Universidad CES

Head Biomedical Engineering Program, Engineering Faculty, Universidad CES. Adjunct Faculty, McGowan Institute for Regenerative Medicine, University of Pittsburgh.

Referencias bibliográficas

Ringo Y, Chilonga K. Burns at KCMC: epidemiology, presentation, management and treatment outcome. Burns J Int Soc Burn Inj. 2014 Aug;40(5):1024-9.

Gillespie P, Carter L, McIntosh C, Gethin G. Estimating the health-care costs of wound care in Ireland. J Wound Care. 2019 Jun 2;28(6):324-30.

Albanna MZ, Holmes IV JH. Skin Tissue Engineering and Regenerative Medicine. New York (NY): Academic Press; 2016.

Halim AS, Khoo TL, Mohd. Yussof SJ. Biologic and synthetic skin substitutes: An overview. Indian J Plast Surg. 2010 Sep;43(Suppl):S23–8.

Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc. 2009 Dec;17(6):763-71.

Yao Z, Niu J, Cheng B. Prevalence of Chronic Skin Wounds and Their Risk Factors in an Inpatient Hospital Setting in Northern China. Adv Skin Wound Care. 2020 Sep;33(9):1-10.

Eaglstein WH, Davis SC, Mehle AL, Mertz PM. Optimal Use of an Occlusive Dressing to Enhance Healing: Effect of Delayed Application and Early Removal on Wound Healing. Arch Dermatol. 1988 Mar 1;124(3):392-5.

Winter GD. Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig. Nature. 1962 Jan;193(4812):293-4.

Forslind B, Lindberg M, Albano RE. Skin, Hair, and Nails: Structure and Function. Boca Ratón (FL): CRC Press; 2014.

Abdo JM, Sopko NA, Milner SM. The applied anatomy of human skin: A model for regeneration. Wound Med. 2020 Mar 1;28:100179.

Le Bitoux MA, Haftek M. Fisiología cutánea: queratinización epidérmica. EMC - Podol. 2008 Jan 1;10(3):1-10.

Mikesh LM, Aramadhaka LR, Moskaluk C, Zigrino P, Mauch C, Fox JW. Proteomic anatomy of human skin. J Proteomics. 2013 Jun 12;84:190-200.

Prost-Squarcioni C, Fraitag S, Heller M, Boehm N. [Functional histology of dermis]. Ann Dermatol Venereol. 2008 Jan;135(1 Pt 2):1S5-20.

Tracy LE, Minasian RA, Caterson EJ. Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound. Adv Wound Care. 2016 Mar 1;5(3):119-36.

Chiquet M, Gelman L, Lutz R, Maier S. From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim Biophys Acta BBA - Mol Cell Res. 2009 May;1793(5):911-20.

Acosta Gómez A. El fibroblasto: su origen, estructura, funciones y heterogeneidad dentro del periodonto. Univ Odontol. 2006 Jun-Dec;25(57):26-33.

Cracowski JL, Roustit M. Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser-Based-Techniques. Microcirculation. 2016 Jul;23(5):337-44.

Butler MG, Isogai S, Weinstein BM. Lymphatic development. Birth Defects Res Part C Embryo Today Rev. 2009 Sep 11;87(3):222-31.

Manzur F, Alvear C, Alayón AN. Adipocitos, obesidad visceral, inflamación y enfermedad cardiovascular. Rev Colomb Cardiol. 2010 Oct;17(5):207-13.

Coppack SW. Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc. 2001 Aug;60(3):349-56.

Karppinen SM, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T. Toward understanding scarless skin wound healing and pathological scarring. F1000Research. 2019 Jun 5;8:F1000 Faculty Rev-787.

Guillamat-Prats R. The Role of MSC in Wound Healing, Scarring and Regeneration. Cells. 2021 Jul;10(7):1729.

Herrero EF, García PY. Manual de Utilización de Hemostáticos y Sellantes en Cirugía Experimental. Madrid (ES): Dykinson; 2019.

Cañedo-Dorantes L, Cañedo-Ayala M. Skin Acute Wound Healing: A Comprehensive Review. Int J Inflamm. 2019 Jun 2;2019:1-15.

Ziegler TR, Pierce GF, Herndon DN, editores. Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications. New York (NY): Springer; 2012.

Freeman SC, Sonthalia S. Histology, Keratohyalin Granules [Internet]. [eBook]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Jun 23]. Available from: NIH.

Rovee DT, Maibach HI. The Epidermis in Wound Healing. Boca Ratón (FL): CRC Press; 2003.

Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, et al. Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care. 2014 Jun 1;3(7):445-64.

Brown TM, Krishnamurthy K. Histology, Dermis. [Internet]. [eBook]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Jul 11]. Available from: NIH.

Kruglikov IL, Scherer PE. Dermal Adipocytes: From Irrelevance to Metabolic Targets? Trends Endocrinol Metab TEM. 2016 Jan;27(1):1-10.

Ud-Din S, Wilgus TA, Bayat A. Mast Cells in Skin Scarring: A Review of Animal and Human Research. Front Immunol. 2020;11.

Chen SX, Zhang LJ, Gallo RL. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense. J Invest Dermatol. 2019 May 1;139(5):1002-9.

Lai-Cheong JE, McGrath JA. Structure and function of skin, hair and nails. Medicine. 2021 Jun 1;49(6):337-42.

Sullivan JV, Myers S. Skin Structure and Function, Wound Healing and Scarring. Plast Surg - Princ Pract. 2022 Jan 1;1-14.

Wong R, Geyer S, Weninger W, Guimberteau JC, Wong JK. The dynamic anatomy and patterning of skin. Exp Dermatol. 2016;25(2):92-8.

Harbour P, Song DH. The Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery [Internet]. 11th ed. New York (NY): McGraw-Hill Education; 2019. Chapter 16, The Skin and Subcutaneous Tissue. [cited 2022 Jul 11]. Available from: https://accesssurgery.mhmedical.com/content.aspx?bookid=2576&sectionid=216206374

Lima T de P de L, Passos MF. Skin wounds, the healing process, and hydrogel-based wound dressings: a short review. J Biomater Sci Polym Ed. 2021 Jun 22;1-16.

Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. Pharmaceutics. 2020 Aug;12(8):735.

Johns Hopkins Medicine [Internet]. [place unknown]: Johns Hopkins; [date unknown]. How Wounds Heal. [cited 2023 Jul 23]. Available from: https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/how-wounds-heal

Herman TF, Bordoni B. Wound Classification [Internet]. [eBook]. Treasure Island (FL): StatPearls Publishing; 2021 [cited 2021 Aug 23]. Available from: NIH.

Koehler J, Ferdinand PB, Achim MG. Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. Eur Polym J. 2018 Mar 1;100:1-11.

Whitney JD. Overview: Acute and Chronic Wounds. Nurs Clin. 2005 Jun 1;40(2):191-205.

Jones RE, Foster DS, Longaker MT. Management of Chronic Wounds—2018. JAMA. 2018 Oct 9;320(14):1481.

Bryant RA, Nix DP. Acute and Chronic Wounds: Current Management Concepts. 5th ed. Maryland Heights (MO): Elsevier Health Sciences; 2015.

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care. Adv Skin Wound Care. 2012 Jul;25(7):304-14.

Gianino E, Miller C, Gilmore J. Smart Wound Dressings for Diabetic Chronic Wounds. Bioengineering. 2018 Jun 26;5(3):51.

Ågren MS, editor. Wound Healing Biomaterials – Volume 1. Therapies and Regeneration [Internet]. Cambridge (GB): Woodhead Publishing; 2016. Chapter 1, Wound Healing. [cited 2021 Aug 26]. Available from: https://www.sciencedirect.com/science/article/pii/B978178242455000001X

Flanagan M. Wound care. Assessment criteria. Nurs Times. 1994 Sep 31;90(35):76-88.

Ngan V. Wounds [Internet]. [place unknow]: DermNet; 2005 [cited 2021 Sep 7]. Available from: https://dermnetnz.org/topics/wounds

Kahn A. Cuts and Puncture Wounds [Internet]. [place unknow]: Healthline; 2019 Nov 1 [cited 2021 Sep 7]. Available from: https://www.healthline.com/health/cuts-and-puncture-wounds

Christopher and Dana Reeve Foundation. Friction and Shearing Skin Injury [Internet]. [place unknown]: Reeve Foundation; [date unknown] [cited 2021 Sep 20]. Available from: https://www.christopherreeve.org/blog/life-after-paralysis/friction-and-shearing-skin-injury

Makati Medical Center. Different Types of Open Wounds and How to Treat Them [Internet]. [place unknown]: Makati Medical Center; 2020 Dec 10 [cited 2021 Sep 20]. Available from: https://www.makatimed.net.ph/news-and-exhibits/news/different-types-of-open-wounds-and-how-to-treat-them

Mayo Clinic Staff. Burns - Symptoms and causes [Internet]. [place unknown]: Mayo Clinic; 2021 [cited 2021 Sep 20]. Available from: https://www.mayoclinic.org/diseases-conditions/burns/symptoms-causes/syc-20370539

Perez E, Fraser M, Novick T. Classification of Burns [Internet]. Rochester (NY): University of Rochester Medical Center; 2021 [cited 2021 Sep 20]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=90&ContentID=P09575

Gedamu H, Abate T, Ayalew E, Tegenaw A, Birhanu M, Tafere Y. Level of nurses’ knowledge on pressure ulcer prevention: A systematic review and meta-analysis study in Ethiopia. Heliyon. 2021 Jul 1;7(7):e07648.

Mayo Clinic Staff. Peptic ulcer - Symptoms and causes [Internet]. [place unknown]: Mayo Clinic; 2021 [cited 2021 Sep 20]. Available from: https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223

Hinton-Sheley P. Pressure Ulcer Prevention and Treatment [Internet]. [place unknown]: News Medical; 2018 [cited 2021 Sep 20]. Available from: https://www.news-medical.net/health/Pressure-Ulcer-Prevention-and-Treatment.aspx

Seth D, Cheldize K, Brown D, Freeman EF. Global Burden of Skin Disease: Inequities and Innovations. Curr Dermatol Rep. 2017 Sep;6(3):204-10.

Mphande FA. Skin Disorders in Vulnerable Populations [Internet]. Singapore: Springer, 2020. Impact of Skin Diseases in Limited Resource Countries [cited 2022 Jun 28]. Available from: https://doi.org/10.1007/978-981-15-3879-7_4

World Health Organization. Quemaduras [Internet]. [place unknown]: World Health Organization [cited 2021 Aug 30]. Available from: https://www.who.int/es/news-room/fact-sheets/detail/burns

Samitsch, C. Data Quality and its Impacts on Decision-Making. New York (NY): SpringerLink, 2014.

Zakrasek EC, Creasey G, Crew JD. Pressure ulcers in people with spinal cord injury in developing nations. Spinal Cord. 2015 Jan;53(1):7-13.

Mesa Pérez JA, Vitarella G, Rosas Guzmán J. Guías ALAD de Pie Diabético [Internet]. Revista de la ALAD. 2010;18(2). Available from: https://www.revistaalad.com/pdfs/xviii2piedab.pdf

Li H, Yao Z, Tan J, Zhou J, Li Y, Wu J, et al. Epidemiology and outcome analysis of 6325 burn patients: a five-year retrospective study in a major burn center in Southwest China. Sci Rep. 2017 Apr 6;7(1):46066.

Williams FN, Herndon DN, Hawkins HK, Lee JO, Cox RA, Kulp GA, et al. The leading causes of death after burn injury in a single pediatric burn center. Crit Care. 2009;13(6):R183.

Navarrete N, Rodriguez N. Epidemiologic characteristics of death by burn injury from 2000 to 2009 in Colombia, South America: a population-based study. Burns Trauma. 2016 Dec 1;4:s41038-016-0033-0.

Ramírez-Blanco CE, Ramírez-Rivero CE, Díaz-Martiínez LA. Causas y sobrevida en pacientes quemados en el centro de referencia del nororiente de Colombia. Cir. plást. Iberolatinoam. 2017;43(1):9.

Bhattacharya S, Mishra RK. Pressure ulcers: Current understanding and newer modalities of treatment. Indian J Plast Surg Off Publ Assoc Plast Surg India. 2015 Apr;48(1):4-16.

Agrawal K, Chauhan N. Pressure ulcers: Back to the basics. Indian J Plast Surg Off Publ Assoc Plast Surg India. 2012;45(2):244-54.

Romero Prada M, Roa C, Alfonso P, Acero G, Huérfano L, Vivas-Consuelo D. Cost-effectiveness analysis of the human recombinant epidermal growth factor in the management of patients with diabetic foot ulcers. Diabet Foot Ankle. 2018 Jan;9(1):1480249.

Silva SY, Rueda LC, Márquez GA, López M, Smith DJ, Calderón CA, et al. Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON. Trials. 2007 Sep 26;8(1):26.

Rajhathy EM, Murray HD, Roberge VA, Woo KY. Healing Rates of Venous Leg Ulcers Managed With Compression Therapy: A Secondary Analysis of Data. J Wound Ostomy Continence Nurs. 2020 Sep/Oct;47(5):477.

Chauhan VS, Goel S, Kumar P, Srivastava S, Shukla VK. The prevalence of pressure ulcers in hospitalised patients in a university hospital in India. J Wound Care. 2005 Jan;14(1):36-7.

Lyder CH, Ayello EA. Patient Safety and Quality - An Evidence-Based Handbook for Nurses [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008. Chapter 12, Pressure Ulcers: A Patient Safety Issue. [cited 2021 Aug 30]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK2650/

Becerra-Bayona SM, Solarte-David VA, Sossa CL, Mateus LC, Villamil M, Pereira J, et al. Mesenchymal stem cells derivatives as a novel and potential therapeutic approach to treat diabetic foot ulcers. Endocrinol Diabetes Metab Case Rep. 2020 Jul 5;2020:19-0164.

Han G, Ceilley R. Chronic Wound Healing: A Review of Current Management and Treatments. Adv Ther. 2017 Mar;34(3):599-610.

Aguilar Salinas CA, Aschner P. Guías ALAD sobre el Diagnóstico, Control y Tratamiento de la Diabetes Mellitus Tipo 2 con Medicina Basada en Evidencia Edición 2019 [Internet]. Revista de la ALAD. 2019. Available from: https://www.revistaalad.com/pdfs/xviii2piedab.pdf

González Consuegra RV, Roa Lizcano KT, López Zuluaga WJ. Estudio de prevalencia de lesiones por presión en un Hospital Universitario, Bogotá-Colombia. Rev Cienc Cuid [Internet]. 2018 Jun 30 [cited 2021 Sep 7];15(2):91-100. Available from: https://revistas.ufps.edu.co/index.php/cienciaycuidado/article/view/1404/1367

Vásconez-Correa MS. Infecciones post quirúrgicas: Análisis a un problema permanente Post-Surgical Infections: Analysis for a Permanent Problem Infecciones post quirúrgicas: Análisis a un problem permanente. 2019 Oct;4(10):17.

Hernández Orozco HG, Castañeda Narváez JL. Prevención de infecciones. Un vistazo a la nueva “Guía global para prevención de infecciones de sitio quirúrgico”. Acta Pediátrica México. 2017 Jan 9;1(1):1.

CDC - National Healthcare Safety Network (NHSN). Surgical Site Infection Event [Internet]. 2023 [cited 2023 Jul 23]. Available from: https://www.cdc.gov/nhsn/pdfs/pscmanual/9pscssicurrent.pdf

CDC. Current HAI Progress Report [Internet]. [place unknown]: CDC;2022 [cited 2023 Jul 25]. Available from: https://www.cdc.gov/hai/data/portal/progress-report.html

CDC. Guideline for Prevention of Surgical Wound Infections. [Internet]. [place unknown]: CDC;2017. Available from: https://www.cdc.gov/infectioncontrol/guidelines/ssi/index.html

Bhangu A, Ademuyiwa AO, Aguilera ML, Alexander P, Al-Saqqa SW, Borda-Luque G, et al. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis. 2018 May;18(5):516-25.

Molina RI, Bejarano M, García O. Infección del sitio operatorio en un hospital nivel II. Rev Colomb Cir. 2005;20(2).

Carvajal R, Londoño Á. Factores de riesgo e infección del sitio quirúrgico en procedimientos de cirugía ortopédica con prótesis. Rev Chil Infectol. 2012 Aug;29(4):395-400.

Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: Mechanisms, signaling, and translation. Sci Transl Med. 2014 Dec 3;6(265):265sr6.

Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21.

Mao AS, Mooney DJ. Regenerative medicine: Current therapies and future directions. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14452-9.

Ohba S, Hojo H, Chung U il. Bioactive factors for tissue regeneration: state of the art. Muscles Ligaments Tendons J. 2012 Oct 16;2(3):193-203.

Climov M, Leavitt T, Molnar J, Orgill D. Skin Tissue Engineering and Regenerative Medicine [Internet]. 1st edition. Amsterdam, (NL): Elsevier; 2016. Chapter 8, Natural Biomaterials for Skin Tissue Engineering. [cited 2021 Sep 7]. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128016541000085

Osorio-Delgado MA, Henao-Tamayo LJ, Velásquez-Cock JA, Cañas-Gutierrez AI, Restrepo-Múnera LM, Gañán-Rojo PF, et al. Aplicaciones biomédicas de biomateriales poliméricos. DYNA. 2017 Apr 1;84(201):241.

Aaliya B, Sunooj KV, Lackner M. Biopolymer composites: a review. Int J Biobased Plast. 2021 Feb 5;3(1):40-84.

Martínez-Correa E. Systemic Classification of Wound Dressings: a Review. Revista Mexicana de Ingeniería Biomédica; 2020;41(1):5-28.

Asadi N, Del Bakhshayesh AR, Davaran S, Akbarzadeh A. Common biocompatible polymeric materials for tissue engineering and regenerative medicine. Mater Chem Phys. 2019;242(1):122528.

Jing Z, Liang Z, Yang L, Du W, Yu T, Tang H, et al. The role of natural polymers in bone tissue engineering. J Controlled Release. 2021 Oct 10; 338:571-582.

Soto F, Rojas H, Cáceres D. Uso de Apósitos en dermatología. Rev Chil Dermatol [Internet]. 2015 [cited 2021 Sep 7];31(3):303-8 Available from: https://www.sochiderm.org/web/revista/31_3/22.pdf

Olivas-Armendariz I. Natural polymers aposites for skin regeneration. Revista Mexicana de Ingeniería Biomédica [Internet]; 2016 [cited 2021 Sep 7];37(3). Available from: http://www.rmib.mx/index.php/rmib/article/view/95

Dussoyer M, Michopoulou A, Rousselle P. Decellularized Scaffolds for Skin Repair and Regeneration. Appl Sci. 2020 May 15;10(10):3435.

Mogoşanu GD, Grumezescu AM. Natural and synthetic polymers for wounds and burns dressing. Int J Pharm. 2014 Mar 25;463(2):127-36.

Moura LIF, Dias AMA, Carvalho E, de Sousa HC. Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review. Acta Biomater. 2013 Jul;9(7):7093-114.

Hurler J, Skalko-Basnet N. Potentials of chitosan-based delivery systems in wound therapy: bioadhesion study. J Funct Biomater. 2012 Jan 6;3(1):37-48.

Ribeiro MP, Espiga A, Silva D, Baptista P, Henriques J, Ferreira C, et al. Development of a new chitosan hydrogel for wound dressing. Wound Repair Regen. 2009 Nov-Dec;17(6):817-24.

Elsner JJ, Berdicevsky I, Zilberman M. In vitro microbial inhibition and cellular response to novel biodegradable composite wound dressings with controlled release of antibiotics. Acta Biomater. 2011 Jan;7(1):325-36.

Wang X, You C, Hu X, Zheng Y, Li Q, Feng Z, et al. The roles of knitted mesh-reinforced collagen-chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats. Acta Biomater. 2013 Aug;9(8):7822-32.

Balaji A, Jaganathan SK, Ismail AF, Rajasekar R. Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries. Int J Nanomedicine. 2016;11:4339-55.

Dornseifer U, Lonic D, Gerstung TI, Herter F, Fichter AM, Holm C, et al. The ideal split-thickness skin graft donor-site dressing: a clinical comparative trial of a modified polyurethane dressing and aquacel. Plast Reconstr Surg. 2011 Oct;128(4):918-24.

Yeoh FH, Lee CS, Kang YB, Wong SF, Cheng SF, Ng WS. Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications. Polymers (Basel). 2020 Aug 17;12(8):E1842.

Tamer TM, Sabet MM, Omer AM, Abbas E, Eid AI, Mohy-Eldin MS, et al. Hemostatic and antibacterial PVA/Kaolin composite sponges loaded with penicillin–streptomycin for wound dressing applications. Sci Rep. 2021 Feb 9;11:3428.

Freedman BR, Mooney DJ. Biomaterials to Mimic and Heal Connective Tissues. Adv Mater. 2019 May;31(19):1806695.

Schoukens G. Advanced Textiles for Wound Care [Internet]. 1st ed. Cambridge (GB): Woodhead Publishing; 2009. Chapter 5: Bioactive dressings to promote wound healing. [cited 2022 Jul 12]. Available from: https://www.sciencedirect.com/science/article/pii/B9781845692711500054

Dhivya S, Padma VV, Santhini E. Wound dressings – a review. BioMedicine (Taipei). 2015 Dec;5(4):22.

Boateng J, Catanzano O. Advanced Therapeutic Dressings for Effective Wound Healing—A Review. J Pharm Sci. 2015 Nov;104(11):3653-80.

Parmaksiz M, Elçin AE, Elçin YM. Skin Stem Cells [Internet]. New York (NY): Humana Press; 2018 Jun 28. Decellularized bSIS-ECM as a Regenerative Biomaterial for Skin Wound Repair. [cited 2021 Aug 18]. Available from: http://link.springer.com/10.1007/7651_2018_147

Shukla SK, Sharma AK, Gupta V, Yashavarddhan MH. Pharmacological control of inflammation in wound healing. J Tissue Viability. 2019 Nov;28(4):218-22.

Flour M, Degreef H. Pharmacological treatment of wounds. Semin Cutan Med Surg. 1998 Dec;17(4):260-5.

Hosgood G. Stages of Wound Healing and Their Clinical Relevance. Vet Clin North Am Small Anim Pract. 2006 Jul;36(4):667-85.

Leise BS. Topical Wound Medications. Vet Clin North Am Equine Pract. 2018 Dec;34(3):485-98.

González Tuero JH. Medicamentos no tradicionales en el tratamiento de pacientes con heridas que curan por segunda intención. MEDISAN. 2014 Nov;18(11):8.

Yazarlu O, Iranshahi M, Kashani HRK, Reshadat S, Habtemariam S, Iranshahy M, et al. Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review. Pharmacol Res. 2021 Aug;105841.

Rodríguez AM, Ballesteros MV, Pérez IE, Olibarrieta IP, Ramírez CD, Sánchez JG, et al. Manual de Protocolos y Procedimientos en el cuidado de las heridas [Internet]. Madrid (ES): Hospital Universitario de Móstoles; 2011. Available from: http://www.madrid.org/bvirtual/BVCM017501.pdf

Ashtikar M, Wacker MG. Nanopharmaceuticals for wound healing – Lost in translation?. Adv Drug Deliv Rev. 2018 Apr;129:194-218.

Okur ME, Karantas ID, Şenyiğit Z, Üstündağ Okur N, Siafaka PI. Recent trends on wound management: New therapeutic choices based on polymeric carriers. Asian J Pharm Sci. 2020 Nov;15(6):661-84.

Margraf A, Zarbock A. Platelets in Inflammation and Resolution. J Immunol. 2019 Nov;203(9):2357-67.

Rodríguez Flores J, Palomar Gallego MA, Torres García-Denche J. Plasma rico en plaquetas: fundamentos biológicos y aplicaciones en cirugía maxilofacial y estética facial. Rev Esp Cir Oral Maxilofac. 2012 Jan;34(1):8-17.

Soares CS, Babo PS, Reis RL, Carvalho PP, Gomes ME. Platelet-Derived Products in Veterinary Medicine: A New Trend or an Effective Therapy?. Trends Biotechnol 2021 Mar;39(3):225-43.

Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci. 2004 Apr;30(2):145-51.

Carr BJ. Platelet-Rich Plasma as an Orthobiologic: Clinically Relevant Considerations. Vet Clin North Am Small Anim Pract, 2022 Jul;52(4):977-95.

Hesseler MJ, Shyam N. Platelet-rich plasma and its utility in medical dermatology: A systematic review. J Am Acad Dermatol. 2019 Sep;81(3):834-46.

Brugués JM. Las espirales del conocimiento. La medicina científica occidental, la medicina homeopática y la medicina tradicional china. Rev Médica Homeopat. 2017 Sep-Dec;10(3):71-8.

Hildebrandt S, Czarnowski G. Alfred Pischinger (1899–1983): An Austrian career in anatomy continuing through National Socialism to postwar leadership. Ann Anat - Anat Anz. 2017 May;211:104-13.

Álvarez Orbea RM, Rodríguez Cadalso AE, Rodríguez Muñoz RC, Rodríguez Jímenéz VS, Calzada M, Cadalso Menéndez JM. A Look to the Bioenergetic Medicine from the Human Physiology. J Pharm Pharmacol. 2020 Dec 28;9(1).

Yan C, Chen X, Zhang CY. Nanjing School: Extracellular microRNA mediates co-evolution between species [Internet]. [place unknown]: Scientific American; 2020 Jun 17 [cited 2021 Aug 23]. Available from: https://www.scientificamerican.com/custom-media/nanjing-school-extracellular-microrna-mediates-co-evolution-between-species/

Fioranelli M, Roccia MG, Flavin D, Cota L. Regulation of Inflammatory Reaction in Health and Disease. Int J Mol Sci. 2021 May 17;22(10):5277.

Naranjo TÁ, Noguera-Salvá R, Guerrero FF. La matriz extracelular: morfología, función y biotensegridad (parte I). Rev Esp Patol. 2009 Oct;42(4):249-61.

Álvaro T, Noguera-Salvá R, Fariñas-Guerrero F. La matriz extracelular: de la mecánica molecular al microambiente tumoral (parte II). Rev Esp Patol. 2010 Jan;43(1):24-32.

Langevin HeleneM, Cornbrooks CarsonJ, Taatjes DouglasJ. Fibroblasts form a body-wide cellular network. Histochem Cell Biol. 2004 Jul; 122(1):7-15.

Wong VW, Longaker MT, Gurtner GC. Soft tissue mechanotransduction in wound healing and fibrosis. Semin Cell Dev Biol. 2012 Dec;23(9):981-6.

Agha R, Ogawa R, Pietramaggiori G, Orgill DP. A Review of the Role of Mechanical Forces in Cutaneous Wound Healing. J Surg Res. 2011 Dec;171(2):700-8.

Chantre CO, Hoerstrup SP, Parker KK. Engineering biomimetic and instructive materials for wound healing and regeneration. Curr Opin Biomed Eng. 2019 Apr;10:97-106.

Giebel J. Mecanotransducción y transducción de señales a través del tejido conjuntivo. Rev Int Acupunt. 2008 Jan;2(1):9-14.

Joseph LH, Paungmali A, Dixon J, Holey L, Naicker AS, Htwe O. Therapeutic effects of connective tissue manipulation on wound healing and bacterial colonization count among patients with diabetic foot ulcer. J Bodyw Mov Ther. 2016 Jul;20(3):650-6.

d’Agostino MC, Craig K, Tibalt E, Respizzi S. Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction. Int J Surg. 2015 Dec;24:147-53.

Auer JA, Stick JA, Kümmerle JM, Prange T. Equine surgery. 5th ed. St. Louis (MO): Elsevier; 2019.

Stanley BJ. Negative Pressure Wound Therapy. Vet Clin North Am Small Anim Pract. 2017 Nov;47(6):1203-20.

Flood MS, Weeks B, Anaeme KO, Aguirre H, Hobizal KB, Jiongco SE, et al. Treatment of Deep Full-thickness Wounds Containing Exposed Muscle, Tendon, and/or Bone Using a Bioactive Human Skin Allograft: A Large Cohort Case Series. Wounds. 2020 Jun;32(6):164-173.

Perez-Amodio S, Rubio N, Vila OF, Navarro-Requena C, Castaño O, Sanchez-Ferrero A, et al. Polymeric Composite Dressings Containing Calcium-Releasing Nanoparticles Accelerate Wound Healing in Diabetic Mice. Adv Wound Care (New Rochelle). 2021 Jun;10(6):301-16.

Teixeira MO, Antunes JC, Felgueiras HP. Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems. Antibiotics. 2021 Mar 2;10(3):248.

Londono R, Badylak SF. Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Ann Biomed Eng. 2015 Mar;43(3):577-92.

Narayan R, editor. Biomedical Materials. New York (NY): Springer; 2009.

Descargas

Publicado

2023-11-10

Cómo citar

1.
Galvis Escobar SM, Molina Sierra JD, Ruíz Soto JP, Rego Londoño MA, Pineda Molina C. Clasificación de heridas cutáneas y técnicas terapéuticas para la reparación de la piel. CES Enf [Internet]. 10 de noviembre de 2023 [citado 2 de mayo de 2024];4(2):26-41. Disponible en: https://revistas.ces.edu.co/index.php/enfermeria/article/view/7262

Número

Sección

Revisión de tema
QR Code
Estadísticas de artículo
Vistas de resúmenes
Vistas de PDF
Descargas de PDF
Vistas de HTML
Otras vistas
Crossref Cited-by logo

Artículos similares

También puede {advancedSearchLink} para este artículo.