Especies reactivas de oxígeno, estrés oxidativo y su relación con la destrucción tisular en periodontitis

Autores/as

Palabras clave:

Especies reactivas de oxígeno, Estrés oxidativo, Periodontitis

Resumen

Durante la periodontitis se liberan mediadores inflamatorios y especies reactivas de oxígeno (ROS), cuando se incrementan producen estrés oxidativo. Este artículo de revisión describe el papel que desempeñan las ROS y el estrés oxidativo en el desarrollo y evolución de la inflamación y lesión tisular durante la periodontitis. Para ello, se realizó una revisión de la literatura en bases de datos como PubMed, ScienceDirect, Wiley Online Library, Springer, Plos one, Nature, Sage journals, Hindawi y Taylor & Francis Online, mostrando los siguientes resultados: las ROS producen daño directo e indirecto a los tejidos periodontales. Los daños directos incluyen peroxidación de lípidos, oxidación de proteínas y del ADN. Los daños indirectos involucran la regulación de las vías de señalización del factor de transcripción nuclear kappa B (NF-κB), la vía de la quinasa c-Jun N-terminal (JNK), las vías del inflamasoma y autofagia provocando la destrucción tisular y creación de un estado proinflamatorio en la periodontitis.

Citas

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Publicado

2020-12-31

Cómo citar

Meñaca Guerrero, L., Suarez Causado, A., & Díaz Caballero, A. J. (2020). Especies reactivas de oxígeno, estrés oxidativo y su relación con la destrucción tisular en periodontitis. CES Odontología, 33(2), 112-127. Recuperado a partir de https://revistas.ces.edu.co/index.php/odontologia/article/view/5237

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