Espécies reativas de oxigênio, estresse oxidativo e sua relação com destruição tecidual na periodontite
DOI:
https://doi.org/10.21615/cesodon.33.2.10Palavras-chave:
Espécies reativas de oxigênio, Estresse oxidativo, PeriodontiteResumo
Durante a periodontite, são liberados mediadores inflamatórios e espécies reativas de oxigênio (EROs), no momento em que eles incrementam produzem estresse oxidativo. Este artigo de revisão descreve o papel que desempenham as EROS e o estresse oxidativo no desenvolvimento e na evolução da inflamação e lesão tecidual durante a periodontite. Por isso, uma revisão da literatura foi realizada em bancos de dados como PubMed, ScienceDirect, Wiley Online Library, Springer, Plos one, Nature, Sage, Hindawi e Taylor & Francis Online, mostrando os seguintes resultados: as EROS produzem dano direto e indireto para os tecidos periodontais. O dano direto inclui peroxidação lipídica, oxidação de proteínas e DNA. O dano indireto involucra a regulação das vias de sinalização do fator de transcrição nuclear kappa B (NF-κB), da via c-Jun N-terminal kinase (JNK), das vias inflamassoma e autofagia, causando destruição tecidual e criação de um estado pró-inflamatório na periodontite.
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