Salivary composition and function in Children with Non-Syndromic CL/P
DOI:
https://doi.org/10.21615/cesodon.5923Keywords:
cleft lip with or without cleft palate, saliva, composition, salivary functionAbstract
Introduction and Objective: Despite the multifactorial etiology of cleft lip with or without cleft palate (CL±P), the genetic component is one of the aspects with the greatest contribution to its appearance. Although saliva plays an important role in oral homeostasis, it is not routinely evaluated in patients with CL±P. Therefore, this study aimed to investigate these characteristics in children with non-syndromic CL±P. Materials and methods: This descriptive study included 17 children with non-syndromic CL±P from Fundación Clínica Noel and 25 children without CL±P. Stimulated (SS) and non-stimulated saliva (NSS) were collected for physicochemical tests, quantification of ions (Ca, Mg and P), total protein and streptococcus count of the mutans group. Results: There were differences statistically significant in the pH of SS and NSS, as well as in total protein concentration and buffer capacity in NSS. The pH (p = 0.002) and buffering capacity (p = 0.023) of NSS of CL±P children decreased, while total protein concentration (p = 0.003) increased compared to the control group. A higher proportion of streptococci from the mutans group was found in NSS of CL±P children (6.39x104 CFU UFC mL-1) compared to the control group (2.21x104 UFC mL-1), although without detecting statistically significant differences (p = 0.243). Conclusions: These findings suggest an alteration in the function and composition of NSS in patients with non-syndromic CL±P; which could possibly be explained from the genetic/biological point of view by an alteration in the salivary glands formation and function in these individuals that requires further investigation.
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