Uso de la homeopatía en ganado lechero como modulador de la función hepática: una revisión



Palabras clave:

hepatoprotector, hígado, producción de leche


La homeopatía se puede utilizar en la producción lechera como una alternativa segura a los antibióticos, capaz de reducir la expansión de la resistencia microbiana, manteniendo la salud de los rebaños. Sin embargo, los compuestos homeopáticos también pueden usarse como protectores del hígado y pueden actuar en la modulación de la función hepática. Los medicamentos homeopáticos a base de hierbas se pueden utilizar como agentes hepatoprotectores, ya que tienen la capacidad de prevenir y reparar los trastornos hepáticos que comúnmente afectan a las vacas lactantes. Así, el conocimiento de las propiedades terapéuticas de las plantas permite la elaboración de preparados homeopáticos, capaces de preservar la salud de los animales de granja. En base a esto, el objetivo de esta revisión es discutir los compuestos vegetales utilizados en homeopatía como hepatoprotectores y sus efectos sobre el metabolismo hepático y la respuesta productiva de los rumiantes lactantes. 


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Biografía del autor/a

Jessyca Karen Pinheiro, Universidade Federal da Paraíba

Universidade Federal da Paraíba, Areia, Paraíba, Brasil. 

Lara Toledo Henriques, Universidade Federal de Juiz de Fora

Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brasil. 

Severino Gonzaga Neto, Universidade Federal da Paraíba

Universidade Federal da Paraíba, Areia, Paraíba, Brasil

Ricardo Dias Signoretti, Agência Paulista de Tecnologia dos Agronegócios

Agência Paulista de Tecnologia dos Agronegócios, Colina, São Paulo, Brasil. 

Juliana Silva de Oliveira, Universidade Federal da Paraíba

Universidade Federal da Paraíba, Areia, Paraíba, Brasil.

Jovanna Karine Pinheiro, Universidade Federal de Campina Grande

Universidade Federal de Campina Grande, Patos, Paraíba, Brasil

Renato Tonhá Alves Júnior, Universidade do Estado do Mato Grosso

Universidade do Estado do Mato Grosso, Pontes e Lacerda, Mato Grosso, Brasil.


Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A et al. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytotherapy Research 2018; 32 (11): 2202-2213.

Abuelo A, Hernández J, Benedito JL, Castillo C. The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation. Journal of Animal Physiology and Animal Nutrition 2015; 99 (6): 1003-1016.

Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK et al. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malaria Journal 2011; 10 (144): 1-12.

Aguilar-Hernández JA, Urías-Estrada JD, López-Soto MA, Barreras A, Plascencia A et al. Evaluation of isoquinoline alkaloid supplementation levels on ruminal fermentation, characteristics of digestion, and microbial protein synthesis in steers fed a high-energy diet. Journal of Animal Science 2016; 94 (1): 267-274.

Aversa R, Petrescu RV, Apicella A, Petrescu FI. About homeopathy or ≪Similia similibus curentur≫. American Journal of Engineering and Applied Sciences 2016; 9 (4): 1-9.

Baumgard LH, Collier RJ, Bauman DE. A 100-Year Review: Regulation of nutrient partitioning to support lactation. Journal of Dairy Science 2017; 100: 10353-10366.

Boyer L, Baghdikian B, Bun SS, Taoubi K, Diaz-Lanza A et al. Chionanthus Virginicus L.: Phytochemical Analysis and Quality Control of Herbal Drug and Herbal Preparations. Natural product communications 2011; 6 (6): 753-758.

Castillo C, Hernandez J, Bravo A, Lopez-Alonso M, Pereira V et al. Oxidative status during late pregnancy and early lactation in dairy cows. The Veterinary Journal 2005; 169: 286-292.

Caporali S 2013, ´Valorization of pomaces from the mechanical extraction of virgin olive oils in dairy animal feeding`. Bologna, pp. 136. Thesis (Dottorato di Scienze e biotecnologie degli alimenti), Alma Mater Studiorum - Università di Bologna.

Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K et al. The silymarin composition… and why does it matter???. Food research international 2017; 100: 339-353.

Chaturvedi MM, Kumar A, Darnay BG, Chainy GB, Agarwal S et al. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-κB activation, IκBα phosphorylation, and degradation. Journal of Biological Chemistry 1997; 272: 30129-30134.

Colombo ML, Bosisio E. Pharmacological activities of Chelidonium majus L. (papaveraceae). Pharmacological research 1996, 33: 127-134.

Côrtes C, Palin MF, Gagnon N, Benchaar C, Lacasse P et al. Mammary gene expression and activity of antioxidant enzymes and concentration of the mammalian lignan enterolactone in milk and plasma of dairy cows fed flax lignans and infused with flax oil in the abomasum. British Journal of Nutrition 2012; 108: 1390-1398.

Cushnie TT, Cushnie B, Lamb AJ. Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial Agents 2014; 5: 377-386.

Cvijanović O, Vladimir-Knežević S, Škoda M, Višnić A. Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chemico-Biological Interactions 2015; 230: 21-29.

Demangeat JL. Towards a rational insight into the paradox of homeopathy. Advances in Complementary & Alternative medicine 2018; 2: 1-13.

Doehring C, Sundrum A. Efficacy of homeopathy in livestock according to peer-reviewed publications from 1981 to 2014. The Veterinary Record 2016; 179: 628.

Drsata J, Ulrichová J, Walterová D. Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase. Journal of enzyme inhibition 1996; 10: 231-237.

Donkin SS 2012, `The role of liver metabolism during transition on postpartum health and performance´. In: 2012 Florida Ruminant Nutrition Symposium Proceedings. 23rd Meeting. 2012. p. 97-106.

Du X, Chen L, Huang D, Peng Z, Zhao C et al. Elevated apoptosis in the liver of dairy cows with ketosis. Cellular Physiology and Biochemistry 2017; 43: 568-578.

Fixsen A. Homeopathy in the age of antimicrobial resistance: Is it a viable treatment for upper respiratory tract infections?. Homeopathy 2018; 107: 099-114.

Fisher P. What is Homeopathy? An Introduction. Frontiers in Bioscience 2012; 4: 1669-1682.

Fox RI, Kang HI. Mechanism of action of antimalarial drugs: inhibition of antigen processing and presentation. Lupus 1993; 2: 9-12.

Ganesan K, Jayachandran M, Xu B. A critical review on hepatoprotective effects of bioactive food components. Critical reviews in food science and nutrition 2018, 58: 1165-1229.

Gazak, R, Walterova D, Kren V. Silybin and silymarin-new and emerging applications in medicine. Current medicinal chemistry 2007; 14: 315-338.

Gemelli JL, Pereira ASC. Principles and uses of homeopathy in beef cattle. A reviwue. Brazilian Journal of Hygiene and Animal Sanity 2018; 12: 327-341.

Gilca M, Gaman L, Panait E, Stoian I, Atanasiu V. Chelidonium majus–an integrative review: traditional knowledge versus modern findings. Complementary Medicine Research 2010; 17: 241-248.

Girish C, Pradhan SC 2017, `Herbal drugs on the liver´. In: Liver Pathophysiology. Academic Press, pp. 605-620.

Gülçin Ý, Elias R, Gepdiremen A, Boyer L, Köksal, E. A comparative study on the antioxidant activity of fringe tree (Chionanthus virginicus L.) extracts. African Journal of Biotechnology 2007; 6: 410-418.

Gülçin I, Elias R, Gepdiremen A, Taoubi K, Köksal, E. Antioxidant secoiridoids from fringe tree (Chionanthus virginicus L.)´. Wood science and technology 2009; 43: 195-200.

Gurung P, De P. Spectrum of biological properties of Cinchona alkaloids: A brief review. J Pharmacogn Phytochem 2017; 6: 162-166.

Hellerbrand C, Schattenberg JM, Peterburs P, Lechner A, Brignoli R. The potential of silymarin for the treatment of hepatic disorders. Clinical Phytoscience 2017; 2: 7-15.

Jyoti BS. Chelidonium majus L. - a review on pharmacological activities and clinical effects. Global Journal of Research on Medicinal Plants & Indigenous Medicine 2013; 2: 238-.

Kushwah P, Das P, Badore NS, Salvekar V, Deshmukh N. Evaluation of antimicrobial activity of Cinchona calisaya bark on Staphylococcus by agar well diffusion method. Pharmaceutical and Biological Evaluations 2016; 3: 272-274.

Kosina P, Walterova D, Ulrichová J, Lichnovský V, Stiborová M et al. Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. Food and Chemical Toxicology 2004; 42: 85-91.

Lees P, Pelligand L, Whiting M, Chambers D, Toutain PL et al. Comparison of veterinary drugs and veterinary homeopathy: part 1. The Veterinary record 2017; 181: 170-.

Lee KW, Kim JS, Oh ST, Kang CW, An BK. Effects of dietary sanguinarine on growth performance, relative organ weight, cecal microflora, serum cholesterol level and meat quality in broiler chickens. The Journal of Poultry Science 2014;:0140073.

Liu G, Aguilar YM, Zhang L, Ren W, Chen, S et al. Dietary supplementation with sanguinarine enhances serum metabolites and antibodies in growing pigs. Journal of Animal Science 2016; 94: 75-78.

Mazzanti G, Di Sotto A, Franchitto A, Mammola CL, Mariani P et al. Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment. Journal of ethnopharmacology 2009; 126: 518-524.

Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CA, Calixto JB. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. Journal of Pharmacology and Experimental Therapeutics 2006; 316: 789-796.

Michels A, Neumann M, Leão GFM, Reck AM, Bertagnon HG et al. Isoquinoline alkaloids supplementation on performance and carcass traits of feedlot bulls. Asian-Australasian journal of animal sciences 2018; 31: 1474.

Nadova S, Miadokova E, Alfoldiova L, Kopaskova M, Hasplova K et al. Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells. Neuroendocrinology Letters 2008; 29: 649-659.

Neumann M, Michels A, Reck AM, Beyer B, Bertagnon HG et al. 658 Effect of feeding isoquinoline alkaloids on performance and carcass characteristics of finishing bulls fed a high-energy diet. Journal of Animal Science 2017; 95: 322-323.

Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW. The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. Journal of ethnopharmacology 2002; 79: 57-67.

Oskoueian E, Abdullah N, Oskoueian A. Effects of flavonoids on rumen fermentation activity, methane production, and microbial population. BioMed research international 2013; 1-8.

Prabha MA, Pereira P, Chowta N, Hegde BM. Clinical implications of hypocalcemia in malaria. Indian Journal of Medical Research 1998; 108: 62.

Penman KG, Bone KM, Lehmann RP. Fringe tree (Chionanthus virginicus L.) stem bark offers a sustainable alternative to root bark. Australian Journal of Medical Herbalism 2008; 20: 107-115..

Petit HV, Gagnon N. Production performance and milk composition of dairy cows fed different concentrations of flax hulls. Animal feed science and technology 2011; 169: 46-52.

Prayitno CH, Suwarno S, Sarwanto D, Hidayatun D. Supplementation of Red Betel Leaf (Piper crocatum) in Dairy Cattle Feed on Fermentation Characteristics by in Vitro. Animal Production Science 2016; 18: 66-74.

Radko L, Cybulski W. Application of silymarin in human and animal medicine´. Journal of Pre-Clinical and Clinical Research 2007; 1: .

Ravishankara MN, Padh H. Antioxidant activity of Cinchona officinalis stem bark extracts. Oriental Pharmacy and Experimental Medicine 2003; 3: 205-211.

Rawling MD, Merrifield DL, Davies SJ. Preliminary assessment of dietary supplementation of Sangrovit® on red tilapia (Oreochromis niloticus) growth performance and health. Aquaculture 2009; 294: 118-122.

Real CM. Homeopatia populacional. Fundamento. Ruptura de um Paradigma. Hora Veterinária 2008; 165: 30-37.

Rogge HI, Aguilar-Hernández JA, Morin-Luogo S, Urías-Estrada JD, Soto ML et al. Effects of supplementation of isoquinoline alkaloids and monensin on microbial protein synthesis, ruminal fermentation and nutrient digestibility in steers fed a finishing diet. Journal of Animal Science 2016; 94: 678-679.

Saleem TM, Chetty CM, Ramkanth SVST, Rajan VST, Kumar KM et al. Hepatoprotective herbs – a review. International Journal of Research in Pharmaceutical Sciences 2010; 1: 1-5.

Sharma C, Rokana N, Chandra M, Singh BP, Gulhane RD et al. Antimicrobial resistance: its surveillance, impact, and alternative management strategies in dairy animals. Frontiers in veterinary science 2018; 4: 237-.

Silva JRM, Bitencourt LL, Oliveira BML, Dias Júnior GS, Lopes F et al. Supplementation of dairy cows with homeopathy: milk somatic cells, cortisol and immunity. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 2011; 4: 805-813.

Schieber M, Chandel, N S. ROS function in redox signaling and oxidative stress. Current biology 2014; 24 (10): R453-R462.

Škottová N, Krečman V. Silymarin as a potential hypocholesterolaemic drug. Physiol Res 1998; 47: 1-7.

Škottová N, Krečman V, Šimánek V. Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 1999; 13: 535-537.

Sordillo LM, Aitken SL. Impact of oxidative stress on the health and immune function of dairy cattle. Veterinary immunology and immunopathology 2009; 128: 104-109.

Staats, J. `A comparative study on the effect of China officinalis 12CH and China officinalis 12CH-parathyroid 4CH complex on blood calcium levels of multiparous dairy cows.´ 2004. Cidade, 88p. Dissertation (Master of Technology: Homeopathy), University of Johannesburg.

Starvaggi Cucuzza L, Motta M, Miretti S, Macchi E, Martignani E et al. Positive effect of silymarin on cell growth and differentiation in bovine and murine mammary cells. Journal of animal physiology and animal nutrition 2010; 94: 111-117.

Surai P. Silymarin as a natural antioxidant: an overview of the current evidence and perspectives. Antioxidants 2015; 4: 204-247.

Taticchi A, Bartocci S, Servili M, Di Giovanni S, Pauselli M et al. Effect on quanti-quality milk and mozzarella cheese characteristics with further increasing the level of dried stoned olive pomace in diet for lactating buffalo. Asian-Australasian journal of animal sciences 2017; 30: 1605.

Tedesco D, Tava A, Galletti S, Tameni M, Varisco G et al. Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows. Journal of dairy science 2004a, 87: 2239-2247.

Tedesco D, Domeneghini C, Sciannimanico D, Tameni M, Steidler S et al. Silymarin, a possible hepatoprotector in dairy cows: biochemical and histological observations. Journal of Veterinary Medicine Series A 2004b; 51: 85-89.

Then M Examination on antioxidant activity in the greater celandine (Chelidonium majus L.) extracts by FRAP method. Acta Biologica Szegediensis 2003; 47: 115-117.

Terramoccia S, Bartocci S, Taticchi A, Di Giovanni S, Pauselli M et al. Use of dried stoned olive pomace in the feeding of lactating buffaloes: effect on the quantity and quality of the milk produced. Asian-Australasian journal of animal sciences 2013; 26: 971.

Ulger I, Onmaz AC, Ayaşan T. Effects of silymarin (Silybum marianum) supplementation on milk and blood parameters of dairy cattle. South African Journal of Animal Science 2017; 6: 758-765.

Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA et al. Global trends in antimicrobial use in food animals. Proceedings of the National Academy of Sciences 2015; 112: 5649-5654.

Vargas-Mendoza N, Madrigal-Santillán E, Morales-González Á, Esquivel-Soto J, Esquivel-Chirino C et al. Hepatoprotective effect of silymarin. World journal of hepatology 2014; 6: 144-

Viksveen P. Antibiotics and the development of resistant microorganisms. Can homeopathy be an alternative?. Homeopathy 2003; 92: 99-107.

Vojtisek B, Hronová B, Hamrik J, Janková, B. Milk thistle (Silybum marianum, L., Gaertn.) in the feed of ketotic cows. Veterinarni medicina 1991; 36: 321-330.

Xu, T. et al. Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows. Journal of dairy science 2017; 100: 9153-9162

Zhang J, Yamada S, Ogihara E, Kurita M, Banno N et al. Biological activities of triterpenoids and phenolic compounds from Myrica cerifera bark. Chemistry & biodiversity 2016; 13: 1601-1609.

Zhan J, Liu M, Wu C, Su X, Zhan K et al. Effects of alfalfa flavonoids extract on the microbial flora of dairy cow rumen. Asian-Australasian journal of animal sciences 2017; 30: 1261.

Wang GX, Rui LI, Zhang, XY. Pharmacokinetics of two ingredients of the compound Chinese herbal medicine transdermal preparation in cows. Agricultural Sciences in China 2009; 8: 1138-1142.

Wang W, Dolan LC, von Alvensleben S, Morlacchini M, Fusconi, G. Safety of standardized Macleaya cordata extract in an eighty‐four‐day dietary study in dairy cows. Journal of animal physiology and animal nutrition 2018; 102: e61-e68.

Wankhade PR, Manimaran A, Kumaresan A, Jeyakumar S, Ramesha KP et al. Metabolic and immunological changes in transition dairy cows: A review. Veterinary world 2017; 10: 1367-1377.

Yormaz S, Bulbuloglu E, Kurutas EB, Ciralik H, Yuzbasioglu MF. The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver. Bratislavske lekarske listy 2012, 113:145-151.




Cómo citar

Pinheiro, J. K., Henriques, L. T., Gonzaga Neto, S., Signoretti, R. D., Oliveira, J. S. de ., Pinheiro, J. K. ., & Alves Júnior, R. T. . (2021). Uso de la homeopatía en ganado lechero como modulador de la función hepática: una revisión. CES Medicina Veterinaria Y Zootecnia, 16(1), 29–46.