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QFormat="true" Name="TOC Heading" /> </w:LatentStyles> </xml><![endif]--> <!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin;} --> <!--[endif] --> <!--StartFragment--><p>Una gran cantidad de fármacos pueden causar nefrotoxicidad en niños. Algunos factores predisponentes como la edad, farmacodinámica, farmacocinética, dosis del fármaco y medicaciones concomitantes, influencian la severidad de la nefrotoxicidad. En los menores, especialmente en el periodo neonatal, la incidencia y etiología de la insuficiencia o falla renal aguda no está bien definida. Sin embargo, se sabe que los neonatos tienen una alta incidencia, especialmente luego de cirugía cardiaca, asfixia severa o parto prematuro. Pero la nefrotoxicidad por fármacos es causa también de insuficiencia renal aguda neonatal, siendo los medicamentos más relacionados los antinflamatorios no esteroideos, aminoglicósidos, vancomicina, anfotericina B, agentes antivirales, inhibidores de la enzima convertidora de angiotensina y los medios de contraste radiológico. Los mecanismos fisiopatológicos directos de nefrotoxicidad incluyen la vasoconstricción intrarrenal, la necrosis tubular aguda, la nefritis intersticial aguda y, con menos frecuencia, la obstrucción tubular. El enalapril, un inhibidor de la enzima convertidora de angiotensina, se utiliza en una variedad de enfermedades cardiovasculares y renales. Es escasa la experiencia con esta medicación en neonatos, pero se deben tener en cuenta sus efectos secundarios, principalmente la alteración de la función renal. Se describe el caso de un recién nacido pretérmino con falla renal aguda posiblemente asociada al uso de enalapril y se presenta una revisión de la literatura.</p><p class="MsoNormal" style="line-height: 200%;"><span style="font-family: Arial;"> </span></p> <p class="MsoNormal" style="line-height: 200%;"><span style="font-family: Arial;"> </span></p> <!--EndFragment-->}, number={1}, journal={CES Medicina}, author={Insignares Vizcaino, Zoila Margarita and Echeverri Cardona, Margarita Maria and Fernandez Laverde, Mauricio}, year={2013}, month={jul.}, pages={83–92} }