Cuidado odontológico de pacientes con trastornos hereditarios de la coagulación

Meliza Andrea Cano-Franco, Gustavo Eduardo Ortiz-Orrego, Sandra Elizabeth González-Ariza

Resumen


Los trastornos hereditarios de la coagulación como la hemofilia que es una enfermedad genética ligada al cromosoma X que se manifiesta por la deficiencia de los factores de la coagulación VIII, IX y XI -Hemofilia A, B y C respectivamente.  , de acuerdo a la cantidad de deficiencia de estos se clasifican en leve, moderada o severa.  Otra de enfermedad que se ve relacionada al trastorno de la coagulación es conocida como enfermedad de Von Willebrand cuya proteína con el mismo nombre se encuentra ausente o disminuido, otro aspecto a resaltar es que esta enfermedad no se encuentra ligada al sexo.

El correcto diagnóstico clínico y exámenes de laboratorio, hace parte de un número de pasos que  debe tener en cuenta el odontólogo para realizar normas de atención adecuadas según el tratamiento de cada paciente, ya sea consulta programada para realizar procedimientos como: operatoria, endodoncia, periodoncia, exodoncias, procedimientos de cirugía oral;  O que se deba realizar tratamientos de urgencias como: heridas de la mucosa, laceraciones en boca, trauma facial, abscesos o celulitis, trauma dentoalveolar, enfocándose no solo en la parte clínica sino en el adecuado manejo del dolor de cada paciente.

DOI: http://dx.doi.org/10.21615/cesodon.30.1.3


Palabras clave


Trastornos hemorrágicos, hemofia, enfermedad de Von Willebrand.

Citas


Gupta A. Epstein JB. Cabay RJ. Bleeding disorders of importance in dental care and related patient managment. JCDA. 2007:73;1:77-83a. www.cda-abc.ca/jcda/vol-73/issue-1/77.html

Israel S. Scwetz N. Boyar R. McNicol A. Bleeding Disorders: Characterization, dental considerations and managment. J Can dent Assoc. 2006;72(9):827-827I. https://www.ncbi.nlm.nih.gov/pubmed/17109803

Nagar LK. Sharma N. Khinchi MP. Khan MS. Kumar A. Haemophilia: an overwiew. Asian J Pharmaceut Res Develop. 2017;5(2):1.10.

Giannelli F, Green PM, Naylor JA. A genetic view on the etiology of the inhibitor complication [letter]. Blood. 1996;87(6):2612-2612. http://www.bloodjournal.org/content/87/6/2612?sso-checked=true

Ingram GI. The history of haemophilia. J Clin Pathol. junio de 1976;29(6):469-479. https://www.ncbi.nlm.nih.gov/pubmed/780375

Darby SC, Kan SW, Spooner RJ, Giangrande PLF, Hill FGH, Hay CRM, et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood. 2007;110(3):815-825. https://www.ncbi.nlm.nih.gov/pubmed/17446349

Coppola A, Di Capua M, De Simone C. Primary prophylaxis in children with haemophilia. Blood Transfus.2008;6(2):4-11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652217/

Fundaciòn de la Hemofilia. Guía para el manejo de la Hemofilia Congénita [Internet]. 2.a ed. Buenos Aires; 2015. Recuperado a partir de: http://www.hemofilia.org.ar/archivos/pdfs/GUIA%202015.PDF

Jover-Cerveró A, Poveda-Roda R, Bagán JV, Jiménez-Soriano Y. Dental treatment of patients with coagulation factor alterations: An update. Medicina Oral, Patología Oral y Cirugía Bucal (Internet). 2007;12(5):380-387. https://www.ncbi.nlm.nih.gov/pubmed/17767103

Stachnik J. Hemophilia: Etiology, complications, and current options in management [Internet]. 2010 July [citado 4 de febrero de 2016]. Disponible en: http://formularyjournal.modernmedicine.com/formulary-journal/news/clinical/clinical-pharmacology/hemophilia-etiology-complications-and-current-

Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood.2004;104(13):3858-3864. https://www.ncbi.nlm.nih.gov/pubmed/15328151

Butenas S, Mann KG. Blood coagulation. Biochemistry Mosc. enero de 2002;67(1):3-12. https://www.ncbi.nlm.nih.gov/pubmed/11841335

Genetics: Linkage Analysis [Internet]. [citado 4 de febrero de 2016]. Disponible en: http://www.practical-haemostasis.com/Genetics/linkage_analysis1.html

Huth-Kuhne A, Baudo F, Collins P, Ingerslev J, Kessler CM, Levesque H, et al. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica.2009;94(4):566-575. https://www.ncbi.nlm.nih.gov/pubmed/19336751

Rossbach H-C. Review of antihemophilic factor injection for the routine prophylaxis of bleeding episodes and risk of joint damage in severe hemophilia A. Vasc Health Risk Manag. 2010;6:59-68.

Rodriguez NI, Hoots WK. Advances in Hemophilia: Experimental Aspects and Therapy. Hematology/oncology clinics of North America. 2010;24(1):181-198. https://www.ncbi.nlm.nih.gov/pubmed/18381091

Martlew VJ. Peri-operative management of patients with coagulation disorders. Br J Anaesth.2000;85(3):446-455. https://watermark.silverhair.com/api/watermark?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_

Saba HI, Tran DQ. Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors. J Blood Med. 2012;3:17-23. https://www.dovepress.com/challenges-and-successes-in-the-treatment-of-hemophilia-the-story-of-a-peer-reviewed-article-JBM

Wildgoose P, Nemerson Y, Hansen LL, Nielsen FE, Glazer S, Hedner U. Measurement of basal levels of factor VIIa in hemophilia A and B patients. Blood. 1992;80(1):25–28. https://www.ncbi.nlm.nih.gov/pubmed/1611090

Kakar, P N, Nishkarsh Gupta, Pradeep Govil, y Vikram Shah.Efficacy and Safety of Tranexamic Acid in Control of Bleeding Following TKR: A Randomized Clinical Trial. Indian J Anaesth.2009;53(6):667-671. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900076/

Rayen R. Hariharan VS. Elavazhagan N. Kamalendran N. Varadajan R. Dental managment of hemophilic child under general anesthesia. J Indian Soc Prev Dent. 2011;29:74-79. https://www.ncbi.nlm.nih.gov/pubmed/21521925

Kalsi H. Nanayakkara L. Pasi KJ. Bowlws L. Hart DP. Access to primary dental care for patients with inherited bleeding disorders. Haemophilia:2012;18:510-515. https://www.ncbi.nlm.nih.gov/pubmed/22151066

Tamagond SB. Hugar SI. Patil A. Huddar SR. Chrismas disease: diagnosis and managment of a haemorrhagic diathesis following dentofacial trauma. BMJ. Case Rep 2015. Published online: doi:10.1136/bcr-2014-203790. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289789/

Rayen R, Hariharan VS, Elavazhagan N, Kamalendran N, Varadarajan R. Dental management of hemophiliac child under general anesthesia. Journal of Indian Society of Pedodontics and Preventive Dentistry.2011;29(1):74-79. https://www.ncbi.nlm.nih.gov/pubmed/21521925

Stubbs M. Lloyd J. A protocol for the dental managment of von Willebrand´s disease, haemophilia A and haemophilia B. Australian Dent J. 2001;46(1):37-40. https://www.ncbi.nlm.nih.gov/pubmed/11355239

Tagliaferri A, Di Perna C, Rivolta GF. Secondary prophylaxis in adolescent and adult haemophiliacs. Blood Transfus.2008;6(2):17-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652219/

Press D. The management of hemophilia in elderly patients. Clinical interventions in aging.2007;2(3):361-368.

Madhok R, York J, Sturrock RD. Haemophilic arthritis. Ann Rheum Dis.1991;50(8):588-591. https://www.ncbi.nlm.nih.gov/pubmed/1888204

Rodríguez-Merchán EC. Management of the orthopaedic complications of haemophilia. J Bone Joint Surg Br. marzo de 1998;80(2):191-6. https://www.ncbi.nlm.nih.gov/pubmed/9546442

Furie B, Limentani SA, Rosenfield CG. A Practical Guide to the Evaluation and Treatment of Hemophilia. Blood.1994;84(1):3-9. https://www.ncbi.nlm.nih.gov/pubmed/8018925

Zafra JMR, Nieto JAC. Guía de actuación en pacientes odontológicos anticoagulados en Atención Primaria. The J Am Dent Assoc. 2010;5(6):272-276.

Gómez-Moreno G, Cañete-Sánchez ME, Guardia J, Castillo-Naveros T, Calvo-Guirado JL. Orthodontic management in patients with haemophilia. About two clinical cases.Med Oral Patol Oral Cir Bucal. 2010;15(3):463-466. https://www.ncbi.nlm.nih.gov/pubmed/20038914

Nematullah A, Alabousi A, Blanas N, Douketis JD, Sutherland SE. Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis. J Can Dent Assoc,2009;75(1):41-50. https://www.ncbi.nlm.nih.gov/pubmed/19239742

El Batawi HY. Minimizing the risk of perioperative bleending in child with hemophilia A during rehabilitation under generl anesthesia: A case report. Int J Clin Pediatric Dent. 2013;6(3):217-222. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086609/

Pedemonte C, Montini C, Castellón L. Manejo de pacientes en tratamiento con anticoagulantes orales previo a cirugía oral. Revista Odontológica Mexicana, 2005;9(4):171-177. http://new.medigraphic.com/cgi-bin/resumen.cgi?IDARTICULO=9445

Givol N, Hirschhorn A, Lubetsky A, Bashari D, Kenet G. Oral surgery-associated postoperative bleeding in haemophilia patients - a tertiary centre’s two decade experience. Haemophilia.2015;21(2):234-240. https://www.ncbi.nlm.nih.gov/pubmed/25470999

Dudeja GP. Dudeja KK. Lakhanoal M. Ali S. Endodontic managment of haemophilic patient- A clinical perspective. J Clin Diag Res. 2014;8(7):zd17-zd18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149158/

Franchini M, Rossetti G, Tagliaferri A, Pattacini C, Pozzoli D, Lorenz C, et al. Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers. Haemophilia.2005;11(5):504-509. https://www.researchgate.net/publication/7631801_Dental_procedures_in_adult_patients_with_hereditary_bleeding_disorders_10_years_experience_in_three_Italian_Hemophilia_Centers

Van Galen KPM. Engelen ET. Mauser-Bunschoten EP. Van Es RJJ. Schutgens REG. Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery of dental extarction (Review). Cochrane Database of systematic reviews 2015, Issue 12 Art No. CD011385. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011385.pub2/pdf

Piot B. Et al. Managment of dental extarctions in patients with bleeding disorders. Oral. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:247-50.

Frachon X. Et al. Managment options for dental extarction in hemophiliacs: A study of 55 extractions (2000-2002). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:270-5. https://www.ncbi.nlm.nih.gov/pubmed/15716831

Hsieh JT. Klein K. Batstone M. Ten-year study of postoperative complications following dental extraction in patients with inherited bleeding disorders. J Oral Maxillofac Surg. 2017. http//dx.doi.org/10.1016/j.ijom2017.04016. https://www.ncbi.nlm.nih.gov/pubmed/28499509

Piot B, Sigaud-Fiks M, Huet P, Fressinaud E, Trossaërt M, Mercier J. Management of dental extractions in patients with bleeding disorders. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics.2002;93(3):247-250.

Djulbegovic B, Goldsmith GJ. Guidelines for management of hemophilia A and B [letter; comment]. Blood.1995;85(2):598-599. http://www.bloodjournal.org/content/85/2/598?sso-checked=true

Plug I, Mauser-Bunschoten EP, Bröcker-Vriends AHJT, Amstel HKP van, Bom JG van der, Diemen-Homan JEM van, et al. Bleeding in carriers of hemophilia. Blood.2006;108(1):52-56.

Bastounis E, Pikoulis E, Leppäniemi A, Alexiou D, Tsigris C, Tsetis A. General surgery in haemophiliac patients. Postgrad Med J.2000;76(898):494-495. https://www.ncbi.nlm.nih.gov/pubmed/10908378

Cahill MR, Colvin BT. Haemophilia. Postgrad Med J.1997;73(858):201-206. https://www.ncbi.nlm.nih.gov/pubmed/9156121

Rick ME, Walsh CE, Key NS. Congenital Bleeding Disorders. Hematology.2003;2003(1):559-574. https://www.ncbi.nlm.nih.gov/pubmed/14633799

Pipe SW. Hemophilia: New Protein Therapeutics. Hematology.2010;2010(1):203-209. https://www.ncbi.nlm.nih.gov/pubmed/21239795

Philipp C. The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues. Hematology.2010;2010(1):191-196. https://www.ncbi.nlm.nih.gov/pubmed/21239793


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