El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

Guillermo Tamayo-Cabeza, Meisser Madera-Anaya, Farith González-Martinez

Resumen


El cáncer bucal posee una alta incidencia y mortalidad a nivel global. A pesar de los avances en el diagnóstico y el pronóstico de esta enfermedad, aún se mantiene una baja tasa de supervivencia de 5 años, lo cual hace necesario el estudio de métodos diagnósticos que sean capaces de detectar la enfermedad en estadios tempranos. Es por esto que avances en proteómica e inmunohistoquímica, han permitido identificar diversos biomarcadores, entre ellos la proteína translocadora (TSPO) mitocondrial de 18kDa, la cual está involucrada en diversos procesos celulares, como el transporte de colesterol, la proliferación celular y la apoptosis. Se ha reportado la presencia de valores alterados de la TSPO en diversos tipos de cáncer, así como la presencia de la TSPO en saliva y tejido de sujetos con cáncer bucal, lo cual representa una oportunidad para entender el proceso de la carcinogénesis bucal e identificar nuevas alternativas para el diagnóstico de esta enfermedad. La presente revisión de tema tiene como objetivo presentar aspectos teóricos en relación con la TSPO como un biomarcador a estudiar en sujetos con cáncer bucal, considerando su implicación en los procesos de apoptosis celular y participación en el estrés oxidativo.

DOI: http://dx.doi.org/10.21615/cesodon.30.1.2


Palabras clave


Cáncer bucal, proteínas salivales, carcinogénesis, estrés oxidativo (DeCs-bvs).

Citas


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