El potencial terapéutico del secretoma de las células troncales

Miguel Angel Martínez-Carreño, Alvaro Andrés Rodriguez Saenz, Juan Carlos Munévar-Niño

Resumen


Las células troncales mesenquimales (CMMs), juegan un papel muy importante en el campo de la medicina regenerativa e ingeniería tisular, puesto que estas células indiferenciadas tienen la increíble capacidad de autorenovarse y de diferenciarse en varios linajes celulares adultos con funciones especializadas. Así mismo, estas células cuentan con la capacidad de inmunomodulación y homing y no tienen riesgo de generar teratoma en contraste con las células troncales embrionarias o las células troncales pluripotenciales inducidas. Del mismo modo, varios autores resaltan las capacidad regenerativa de los productos de estas células conocido como secretoma. Estos productos juegan una papel muy importante en procesos de cicatrización y neoangiogénesis, por lo que resultan ideales para aplicarlo en  terapias basada en regeneración y reparación de tejidos y órganos.

 

The therapeutic potential of stem cells secretome

Mesenchymal stem cells (MSC’s) play an important role in regenerativemedicine and tissue engineering, since these undifferentiated cells havethe ability to self-renew and differentiate into several adult cell lineageswith different, specialized functions. These cells have immunomodulationand homing capacities without the risk of generating teratomas, in contrastto embryonic stem cells or induced pluripotent stem cells. Severalauthors also highlight the regenerative capacity of products of these cells,known as secretome. These products play a very important role in healingprocesses and angiogenesis, making them ideal for application in therapiesbased on regeneration and repair of tissues and organs. The presentreview makes a recount of the state of the art on the processes of immodulationproduced from these cell products.

Keywords: Mesenchymal Stem Cells, Tissue Engineering, Secretome, Immunomodulation.


Palabras clave


Células troncales mesenquimales; ingeniería tisular; secretoma; inmunomodulación.

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Referencias


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