Porphyromonas gingivalis y enfermedades sistémicas

Mary Orrego Cardozo, María Alejandra Parra Gil, Yenny Paola Salgado Morales, Erika Muñoz Guarín, Vanessa Fandiño Henao


Porphyromonas gingivalis (P.g.) es un cocobacilo Gram negativo que habita el surco gingival. Susfactores patogénicos estructurales como las fimbrias facilitan su adhesión al tejido, mientras que factoresde secreción como proteasas y hialuronidasas hidrolizan componentes del tejido periodontal, causandodaño tisular y pérdida de soporte dentario. Algunos componentes estructurales de Porphyromonascomo los lipopolisacáridos se han asociado a enfermedades sistémicas. En esta revisión se presentauna descripción de los factores patogénicos de Porphyromonas gingivalis y su relación con enfermedadpulmonar, ateroesclerosis y parto pretérmino, haciendo énfasis en los mecanismos moleculares de dichaasociación.


Porphyromonas gingivalis and systemic diseases


Porphyromonas gingivalis (P.g.) is a gram-negative coccobacillus that resides in the gingival sulcus. Someof its structural pathogenic factors like fimbriae allow its adhesion to the tissues of the gingival sulcus, whereP.g. secretes proteases and hyaluronidases that hydrolyze components of the periodontal tissues, leadingto tissue damage and loss of teeth support. Some bacterial components such as lipopolysaccharides havebeen associated with systemic diseases. This review focuses on the molecular mechanisms linking thepathogenic factors of Porphyromonas gingivalis to diseases such as atherosclerosis, pulmonary diseaseand preterm birth.

Keywords:Porphyromonas gingivalis, periodontitis, atherosclerosis, preterm birth, pathogenic factors, pulmonarydisease

Palabras clave

Porphyromonas gingivalis, periodontitis, ateroesclerosis, nacimiento prematuro, factores patogénicos, enfermedad pulmonar

Texto completo:



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