Porphyromonas gingivalis y enfermedades sistémicas

Mary Orrego Cardozo, María Alejandra Parra Gil, Yenny Paola Salgado Morales, Erika Muñoz Guarín, Vanessa Fandiño Henao

Resumen


Porphyromonas gingivalis (P.g.) es un cocobacilo Gram negativo que habita el surco gingival. Susfactores patogénicos estructurales como las fimbrias facilitan su adhesión al tejido, mientras que factoresde secreción como proteasas y hialuronidasas hidrolizan componentes del tejido periodontal, causandodaño tisular y pérdida de soporte dentario. Algunos componentes estructurales de Porphyromonascomo los lipopolisacáridos se han asociado a enfermedades sistémicas. En esta revisión se presentauna descripción de los factores patogénicos de Porphyromonas gingivalis y su relación con enfermedadpulmonar, ateroesclerosis y parto pretérmino, haciendo énfasis en los mecanismos moleculares de dichaasociación.

 

Porphyromonas gingivalis and systemic diseases

Abstract

Porphyromonas gingivalis (P.g.) is a gram-negative coccobacillus that resides in the gingival sulcus. Someof its structural pathogenic factors like fimbriae allow its adhesion to the tissues of the gingival sulcus, whereP.g. secretes proteases and hyaluronidases that hydrolyze components of the periodontal tissues, leadingto tissue damage and loss of teeth support. Some bacterial components such as lipopolysaccharides havebeen associated with systemic diseases. This review focuses on the molecular mechanisms linking thepathogenic factors of Porphyromonas gingivalis to diseases such as atherosclerosis, pulmonary diseaseand preterm birth.

Keywords:Porphyromonas gingivalis, periodontitis, atherosclerosis, preterm birth, pathogenic factors, pulmonarydisease


Palabras clave


Porphyromonas gingivalis, periodontitis, ateroesclerosis, nacimiento prematuro, factores patogénicos, enfermedad pulmonar

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Referencias


Nishiyama S, Murakami Y, Nagata H, Shizukuishi S, Kawagishi I, Yoshimura F. Involvement of minor

components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions.

Microbiology. 2007;153(Pt 6):1916-25.

Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S, Yoshimura F, et al. Fimbrial proteins of

porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to

persist in macrophages. Journal of immunology. 2007;179(4):2349-58.

Ramos Perfecto D, Moromi Nakata H, Martínez Cadillo E. Porphyromonas gingivalis: patógeno

predominante en la periodontitis crónica. Odontología Sanmarquina. 2014;14(1):34-8.

Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas

gingivalis. Microbiology and molecular biology reviews : MMBR. 1998;62(4):1244-63.

Kuramitsu H, Yoneda M, Madden T. Proteases and collagenases of Porphyromonas gingivalis.

Advances in dental research. 1995;9(1):37-40.

oshimura F, Takahashi Y, Hibi E, Takasawa T, Kato H, Dickinson DP. Proteins with molecular masses of

and 80 kilodaltons encoded by genes downstream from the fimbrilin gene (fimA) are components

associated with fimbriae in the oral anaerobe Porphyromonas gingivalis. Infection and immunity.

;61(12):5181-9.

Takahashi Y, Yoshimura F, Kawanami M, Kato H. Detection of fimbrilin gene (fimA) in Porphyromonas

(Bacteroides) gingivalis by Southern blot analysis. Journal of periodontal research. 1992;27(6):

-603.

Watanabe K, Onoe T, Ozeki M, Shimizu Y, Sakayori T, Nakamura H, et al. Sequence and product

analyses of the four genes downstream from the fimbrilin gene (fimA) of the oral anaerobe

Porphyromonas gingivalis. Microbiology and immunology. 1996;40(10):725-34.

Nishikawa K, Yoshimura F, Duncan MJ. A regulation cascade controls expression of Porphyromonas

gingivalis fimbriae via the FimR response regulator. Molecular microbiology. 2004;54(2):546-60.

Wu J, Lin X, Xie H. Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR twocomponent

system. FEMS microbiology letters. 2007;271(2):214-21.

Wang M, Liang S, Hosur KB, Domon H, Yoshimura F, Amano A, et al. Differential virulence and

innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. Oral

microbiology and immunology. 2009;24(6):478-84.

Kerr JE, Abramian JR, Dao DH, Rigney TW, Fritz J, Pham T, et al. Genetic exchange of fimbrial alleles

exemplifies the adaptive virulence strategy of Porphyromonas gingivalis. PloS one. 2014;9(3):e91696.

Rosen G, Sela MN. Coaggregation of Porphyromonas gingivalis and Fusobacterium nucleatum PK

is mediated by capsular polysaccharide and lipopolysaccharide. FEMS microbiology letters.

;256(2):304-10.

Brunner J, Wittink FR, Jonker MJ, de Jong M, Breit TM, Laine ML, et al. The core genome of the

anaerobic oral pathogenic bacterium Porphyromonas gingivalis. BMC microbiology. 2010;10:252.

Naito Y, Tohda H, Okuda K, Takazoe I. Adherence and hydrophobicity of invasive and noninvasive

strains of Porphyromonas gingivalis. Oral microbiology and immunology. 1993;8(4):195-02.

Park Y, Lamont RJ. Contact-dependent protein secretion in Porphyromonas gingivalis. Infection and

immunity. 1998;66(10):4777-82.

Veith PD, Chen YY, Gorasia DG, Chen D, Glew MD, O'Brien-Simpson NM, et al. Porphyromonas

gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins

and carry a cargo enriched with virulence factors. Journal of proteome research. 2014;13(5):

-32.

Furuta N, Takeuchi H, Amano A. Entry of Porphyromonas gingivalis outer membrane vesicles into

epithelial cells causes cellular functional impairment. Infection and immunity. 2009;77(11):4761-70.

Lantz MS, Allen RD, Duck LW, Switalski LM, Hook M. Porphyromonas gingivalis surface components

bind and degrade connective tissue proteins. Journal of periodontal research. 1991;26(3 Pt 2):283-5.

Lantz MS, Allen RD, Duck LW, Blume JL, Switalski LM, Hook M. Identification of Porphyromonas

gingivalis components that mediate its interactions with fibronectin. Journal of bacteriology.

;173(14):4263-70.

Grenier D, Labbe S, Mouton C, Meyrand D. Hydrolytic enzymes and lectin-binding activity of blackpigmented

anaerobic rods. Microbiology. 1994;140 ( Pt 4):873-8.

Pavloff N, Potempa J, Pike RN, Prochazka V, Kiefer MC, Travis J, et al. Molecular cloning and

structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis

as a proteinase-adhesin polyprotein. The Journal of biological chemistry. 1995;270(3):1007-10.

Graves DT, Delima AJ, Assuma R, Amar S, Oates T, Cochran D. Interleukin-1 and tumor necrosis

factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in

experimental periodontitis. Journal of periodontology. 1998;69(12):1419-25.

disease and risk of very preterm delivery. Obstetrics and gynecology. 2006;107(1):29-36.

Offenbacher S, Beck JD, Moss K, Mendoza L, Paquette DW, Barrow DA, et al. Results from the

Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial

to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease.

Journal of periodontology. 2009;80(2):190-01.

Premoli G, Villarreal J, González A. Proteina c reactiva y su relacion con la enfermedad periodontal y

aterosclerosis. Acta Odontológica Venezolana. 2008;46(1):92-93.

De Freitas RBC, Luz de Aquino AR, Costa de Lima K, da Fonte Porto Carreiro A. Proteína C-reactiva

ultrasensible en pacientes con y sin periodontitis crónica severa generalizada. 2009; 21(3):145-155.

Smalley JW, Shuttleworth CA, Birss AJ. Collagenolytic activity of the extracellular vesicles of

Bacteroides gingivalis W50 and an avirulent variant W50/BE1. Archives of oral biology. 1989;34(7):

-83.

Larjava H, Hakkinen L, Rahemtulla F. A biochemical analysis of human periodontal tissue

proteoglycans. Biochem J. 1992;284:267-74.

Cutler CW, Kalmar JR, Genco CA. Pathogenic strategies of the oral anaerobe, Porphyromonas

gingivalis. Trends in microbiology. 1995;3(2):45-51.

Sandros J, Papapanou P, Dahlen G. Porphyromonas gingivalis invades oral epithelial cells in vitro.

Journal of periodontal research. 1993;28(3):219-26.

Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, et al. Low-abundance biofilm

species orchestrates inflammatory periodontal disease through the commensal microbiota and

complement. Cell host & microbe. 2011;10(5):497-06.

Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X, et al. Serine lipids of

Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands. Infection and immunity.

;81(9):3479-89.

Gibson FC, 3rd, Genco CA. Porphyromonas gingivalis mediated periodontal disease and

atherosclerosis: disparate diseases with commonalities in pathogenesis through TLRs. Current

pharmaceutical design. 2007;13(36):3665-75.

Offenbacher S, Beck JD, Jared HL, Mauriello SM, Mendoza LC, Couper DJ, et al. Effects of periodontal

therapy on rate of preterm delivery: a randomized controlled trial. Obstetrics and gynecology.

;114(3):551-9.

Offenbacher S, Collins JG, Arnold RR. New clinical diagnostic strategies based on pathogenesis of

disease. Journal of periodontal research. 1993;28(6 Pt 2):523-35.

Lopez R, Oyarzun M, Naranjo C, Cumsille F, Ortiz M, Baelum V. Coronary heart disease and periodontitis

-- a case control study in Chilean adults. Journal of clinical periodontology. 2002;29(5):468-73.

Lamont RJ, Oda D, Persson RE, Persson GR. Interaction of Porphyromonas gingivalis with gingival

epithelial cells maintained in culture. Oral microbiology and immunology. 1992;7(6):364-7.

Lamont RJ, Chan A, Belton CM, Izutsu KT, Vasel D, Weinberg A. Porphyromonas gingivalis invasion

of gingival epithelial cells. Infection and immunity. 1995;63(10):3878-85.

Bermúdez V, Leal E, Bermúdez F, Cano C, Cabrera M, Ambard M, et al. Enfermedad Periodontal

como factor de riesgo para la Aterosclerosis. AVFT. 2003;22(2):153-62.

Miyakawa H, Honma K, Qi M, Kuramitsu HK. Interaction of Porphyromonas gingivalis with lowdensity

lipoproteins: implications for a role for periodontitis in atherosclerosis. Journal of periodontal

research. 2004;39(1):1-9.

Mattila KJ. Viral and bacterial infections in patients with acute myocardial infarction. Journal of internal

medicine. 1989;225(5):293-6.

Emingil G, Buduneli E, Aliyev A, Akilli A, Atilla G. Association between periodontal disease and acute

myocardial infarction. Journal of periodontology. 2000;71(12):1882-6.

Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesaniemi YA, Syrjala SL, et al. Association between

dental health and acute myocardial infarction. Bmj. 1989;298(6676):779-81.

Padilla C, Lobos O, Hubert E, Gonzalez C, Matus S, Pereira M, et al. Periodontal pathogens in

atheromatous plaques isolated from patients with chronic periodontitis. Journal of periodontal

research. 2006;41(4):350-3.

Verma S, Li SH, Badiwala MV, Weisel RD, Fedak PW, Li RK, et al. Endothelin antagonism and

interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation.

;105(16):1890-6.

Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular

disease. Journal of periodontology. 1996;67(10 Suppl):1123-37.

Rahman AU, Rashid S, Noon R, Samuel ZS, Lu B, Borgnakke WS, et al. Prospective evaluation of the

systemic inflammatory marker C-reactive protein in patients with end-stage periodontitis getting teeth

replaced with dental implants: a pilot investigation. Clinical oral implants research. 2005;16(1):128-31.

Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, Nardin ED. Periodontal infections contribute

to elevated systemic C-reactive protein level. Journal of periodontology. 2001;72(9):1221-7.

DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary

heart disease and mortality. Bmj. 1993;306(6879):688-91.

Meikle MC, Heath JK, Reynolds JJ. Advances in understanding cell interactions in tissue resorption.

Relevance to the pathogenesis of periodontal diseases and a new hypothesis. Journal of oral

pathology. 1986;15(5):239-50.

Pussinen PJ, Jauhiainen M, Vilkuna-Rautiainen T, Sundvall J, Vesanen M, Mattila K, et al. Periodontitis

decreases the antiatherogenic potency of high density lipoprotein. Journal of lipid research.

;45(1):139-47.

Li L, Michel R, Cohen J, Decarlo A, Kozarov E. Intracellular survival and vascular cell-to-cell

transmission of Porphyromonas gingivalis. BMC Microbiology. 2008;8:26.

Li L, Messas E, Batista EL, Jr., Levine RA, Amar S. Porphyromonas gingivalis infection accelerates

the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model.

Circulation. 2002;105(7):861-7.

Pussinen PJ, Jousilahti P, Alfthan G, Palosuo T, Asikainen S, Salomaa V. Antibodies to periodontal

pathogens are associated with coronary heart disease. Arteriosclerosis, thrombosis, and vascular

biology. 2003;23(7):1250-4.

Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA. Periodontal disease is associated

with brachial artery endothelial dysfunction and systemic inflammation. Arteriosclerosis, thrombosis,

and vascular biology. 2003;23(7):1245-9.

Meurman JH, Sanz M, Janket SJ. Oral health, atherosclerosis, and cardiovascular disease. Critical

reviews in oral biology and medicine : an official publication of the American Association of Oral

Biologists. 2004;15(6):403-13.

O'Mahony DS, Pham U, Iyer R, Hawn TR, Liles WC. Differential constitutive and cytokine-modulated

expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages.

International journal of medical sciences. 2008;5(1):1-8.

Scannapieco FA. Role of oral bacteria in respiratory infection. Journal of periodontology.

;70(7):793-02.

Huxley EJ, Viroslav J, Gray WR, Pierce AK. Pharyngeal aspiration in normal adults and patients with

depressed consciousness. The American journal of medicine. 1978;64(4):564-8.

Mojon P. Oral health and respiratory infection. J Can Dent Assoc. 2002;68(6):340-5.

Scannapieco FA, Rethman MP. The relationship between periodontal diseases and respiratory

diseases. Dentistry today. 2003;22(8):79-83.

Hajishengallis G, Wang M, Bagby GJ, Nelson S. Importance of TLR2 in early innate immune response

to acute pulmonary infection with Porphyromonas gingivalis in mice. Journal of immunology.

;181(6):4141-9.

Hajishengallis G, Wang M, Liang S. Induction of distinct TLR2-mediated proinflammatory and

proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. Journal of

immunology. 2009;182(11):6690-6.

Wilder R, Robinson C, Jared HL, Lieff S, Boggess K. Obstetricians' knowledge and practice

behaviors concerning periodontal health and preterm delivery and low birth weight. J Dent hyg Fall.

;81(4):81-95.

Castaldi JL, Bertin MS, Gimenez F, Lede R. [Periodontal disease: Is it a risk factor for premature labor,

low birth weight or preeclampsia?]. Revista panamericana de salud publica = Pan American journal

of public health. 2006;19(4):253-8.

Ovalle A, Gamonal J, Martinez MA, Silva N, Kakarieka E, Fuentes A, et al. [Relationship between

periodontal diseases and ascending bacterial infection with preterm delivery]. Revista medica de Chile. 2009;137(4):504-14.

Zermeño JdJ, Flores CdC, Saldívar D, Soria JA, Garza M, Iglesias JL. Enfermedad periodontal como

factor de riesgo para presentar resultados perinatales adversos. Revista chilena de obstetricia y

ginecología. 2011;76(5):338-43.

Rascon C, Saraya L. Asociación de la presencia de aggregatibacter actinomycetemcomitans,

porphyromonas gingivalis y prevotella intermedia en conjunto con la enfermedad periodontal

con embarazo pretérmino y producto de bajo peso: [Master Thesis] Url: http:eprint.unal.mxid

eprint2612 Universidad Autónoma de Nuevo León; 2012.

Flores J, Oteo A, Mateos L, Bascones A. Relación entre enfermedad periodontal y parto prematuro.

Bajo peso al nacimiento: una revisión de la literatura. Avances en Periodoncia [revista en la

Internet]. 2004 Ago [citado 2015 Jul 30] ; 16(2): 93-105. Disponible en: http://scielo.isciii.es/scielo.

php?script=sci_arttext&pid=S1699-65852004000200004&lng=es

Paquette D. Periodontal disease and the risk for adverse pregnancy outcomes. Grand Rounds Oral-

Sys Med. 2006;4:14-25.

Tarannum F, Faizuddin M. Effect of periodontal therapy on pregnancy outcome in women affected

by periodontitis. Journal of periodontology. 2007;78(11):2095-103.

Agueda A, Ramon JM, Manau C, Guerrero A, Echeverria JJ. Periodontal disease as a risk factor

for adverse pregnancy outcomes: a prospective cohort study. Journal of clinical periodontology.

;35(1):16-22.

Robles Ruiz JJ, Salazar Silva F, Proaño de Casalino D. Enfermedad periodontal como factor de riesgo

de ratardo del crecimiento intrauterino. Rev Estomatol Herediana. 2004;14(1-2):27-34.

Collins JG, Windley HW, 3rd, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis

infection on inflammatory mediator response and pregnancy outcome in hamsters. Infection and

immunity. 1994;62(10):4356-61.

Peña M, Peña L, Díaz Á, Torres D, Lao N. La enfermedad periodontal como riesgo de enfermedades

sistémicas. Rev Cubana Estomatol [revista en la Internet]. 2008 Mar [citado 2015 Jul 30] ; 45(1): . Disponible

en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072008000100006&lng=es.

Peña M, Ortiz C, Peña L, Pascual V, Toirac A. La enfermedad periodontal como factor de riesgo para

partos pretérmino y nacimiento de niños con bajo peso [artículo en línea]. MEDISAN 2006;10(esp).

bvs.sld.cu/revistas/san/vol10_(esp)_06/san04(esp)06.htm> [consulta: 2015 Jul 30].




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